Bosutinib

SKU
B-2208
  • CAS:380843-75-4
  • Formula:C26H29Cl2N5O3
  • MW:530.45
  • Appearance:White to off-white Solid
  • Purity:99% by HPLC

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Product Name Qty
Bosutinib
25 mg
$217.76
Bosutinib
5 mg
$106.09
Bosutinib (SKI-606) is a novel tyrosine kinase inhibitor. Bosutinib can overcome not only Bcr-Abl-dependent mechanisms of resistance, but also those that are Bcr-Abl-independent.It is used to treat patients with chronic myelogenous leukemia (CML) who demonstrate resistance to Imatinib or develop resistance during treatment.
More Information
Alternate Name/Synonyms
SKI-606
SKU
B-2208
CAS #
380843-75-4
Chemical Name
4-(2,4-DICHLORO-5-METHOXYANILINO)-6-METHOXY-7-[3-(4-METHYLPIPERAZIN-1-YL)PROPOXY]QUINOLINE-3-CARBONITRILE
Chemical Formula
C26H29Cl2N5O3
Molecular Weight
530.45
Appearance
White to off-white Solid
Purity
99% by HPLC
Solubility
DMSO (30 mg/ml) or EtOH (10 mg/ml)
Stability
N/A
Melting Point
131-134 °C
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
Bosutinib (SKI-606) is a potent c-Abl, Bcr-Abl, and Src-Abl kinase inhibitor, shown to effectively interfere with the progress of chronic myelogenous leukemia (CML)
MDL NUMBER
MFCD07367846
CHEMACX
X1450615-5
INCHI
InChI=1S/C26H29Cl2N5O3/c1-32-6-8-33(9-7-32)5-4-10-36-25-13-21-18(11-24(25)35-3)26(17(15-29)16-30-21)31-22-14-23(34-2)20(28)12-19(22)27/h11-14,16H,4-10H2,1-3H3,(H,30,31)
SMILES
CN1CCN(CC1)CCCOc2cc3c(cc2OC)c(c(cn3)C#N)Nc4cc(c(cc4Cl)Cl)OC
Peptide sequence
Not Applicable
RTECS
VB0990000
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Protect from light and moisture
Promo text for AGS discount
N/A
GHS PICTOGRAMS
Handling Protect from light and moisture
UN #'S Not Applicable
Packing Group Not Applicable
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