BSO; NSC 326231; 2S-amino-4-(S-butylsulfonimidoyl)-butanoic acid
83730-53-4
222.3
C8H18N2O3S
PBS (pH 7.2)
-20°C
L-Buthionine-sulfoximine is a sulfoximine and irreversible inhibitor of gamma-glutamylcysteine synthetase. Studies show methylglyoxal (MG) activated caspase-3 is enhanced in the presence of BSO. It has been reported that BSO can augment HIV-1 activation through class I HDACIs, and that it can sensitize human breast cancer cells that are anti-hormone resistant to estrogen-induced apoptosis.
Buthionine sulfoximine may also be used to increase the sensitivity of parasites to oxidative antiparasitic drugs.
0.1 lbs
Research or further manufacturing use only, not for food or drug use.
