Buthionine Sulfoximine (BSO)

SKU
B-1081
  • CAS:83730-53-4
  • Formula:C8H18N2O3S
  • MW:222.30 Da
  • Appearance:White to off-white solid
  • Purity:≥98%

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Product Name Qty
L-Buthionine-(S,R)-Sulfoximine
1 g
$299.99
L-Buthionine-(S,R)-Sulfoximine
10 g
$2,400.00

Description

L-Buthionine-sulfoximine is a sulfoximine and irreversible inhibitor of gamma-glutamylcysteine synthetase.

Studies show methylglyoxal (MG) activated caspase-3 is enhanced in the presence of BSO. It has been reported that BSO can augment HIV-1 activation through class I HDACIs, and that it can sensitize human breast cancer cells that are anti-hormone resistant to estrogen-induced apoptosis.

Applications

Buthionine sulfoximine may also be used to increase the sensitivity of parasites to oxidative antiparasitic drugs.

More Information
Alternate Name/Synonyms
BSO; L-BSO; L-Buthionine-sulfoximine; L-Buthionine-(S,R)-Sulfoximine
SKU
B-1081
CAS #
83730-53-4
Chemical Name
(2S)-2-Amino-4-(S-butylsulfonimidoyl)butanoic acid
Chemical Formula
C8H18N2O3S
Molecular Weight
222.30 Da
Appearance
White to off-white solid
Purity
≥98%
Solubility
Aqueous Acid, Water
Melting Point
210 - 213‚°C (dec.)
Preparation
N/A
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
Cytotoxic effects of glutathione synthesis inhibition by L-buthionine-(SR)-sulfoximine on tumor cells
Merck Index
N/A
MDL NUMBER
MFCD00067000
CHEMACX
X1014401-7
INCHI
InChI=1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12)/t7-,14?/m0/s1
SMILES
CCCCS(=N)(=O)CC[C@@H](C(=O)O)N
Peptide sequence
Not Applicable
RTECS
EK7713440
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Use only in area provided with appropriate exhaust ventilation. Keep away from heat and source of ignition. Empty containers pose a fire risk, evaporate residue under fume hood. Ground all equipment containing material. Do not breathe dust.
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
Handling Use only in area provided with appropriate exhaust ventilation. Keep away from heat and source of ignition. Empty containers pose a fire risk, evaporate residue under fume hood. Ground all equipment containing material. Do not breathe dust.
UN #'S Not Applicable
Packing Group Not Applicable
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