p300/CBP inhibitor, C-646

SKU
C-2212
  • CAS:328968-36-1
  • Formula:C24H19N3O6
  • MW:445.42
  • Appearance:Red Solid
  • Purity:98% by NMR
Product Name Qty
C-646
1 mg
$96.82
C-646
5 mg
$387.28

Cell-permeable. A reversible, p300/CBP (CREB-binding protein) histone acetyltransferase (HAT) inhibitor (K = 400 nM). Specific inhibition to p300 (86%) compared to N-acetyltransferase, PCAF, GCN5, Rtt109, Sas or MOZ histone acetyltransferases (10%). Suppresses histone H3 and H4 acetylation in mouse fibroblast cell lines.

More Information
Alternate Name/Synonyms
(E)-4-(4-((5-(4,5-Dimethyl-2-nitrophenyl)furan-2-yl)-methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid; C646, p300/CBP Inhibitor
SKU
C-2212
CAS #
328968-36-1
Chemical Name
(E)-4-(4-((5-(4,5-Dimethyl-2-nitrophenyl)furan-2-yl)-methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid
Chemical Formula
C24H19N3O6
Molecular Weight
445.42
Appearance
Red Solid
Purity
98% by NMR
Solubility
DMSO (25 mM)
Storage Temp
-20°C
USE
C646 is a competitive histone acetyltransferase (HAT) p300/CBP inhibitor use in cancer
MDL NUMBER
MFCD01784780
CHEMACX
X3304905-5
INCHI
InChI=1S/C24H19N3O6/c1-13-10-20(21(27(31)32)11-14(13)2)22-9-8-18(33-22)12-19-15(3)25-26(23(19)28)17-6-4-16(5-7-17)24(29)30/h4-12H,1-3H3,(H,29,30)/b19-12-
SMILES
Cc1cc(c(cc1C)[N+](=O)[O-])c2ccc(o2)/C=C3/C(=NN(C3=O)c4ccc(cc4)C(=O)O)C
UN #'S
UN 3077
PACKING GROUP
III
Handling
Protect from light and air
GHS PICTOGRAMS
Handling Protect from light and air
UN #'S UN 3077
Packing Group III
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