C75, FAS Inhibitor

SKU
C-1373
  • CAS:191282-48-1
  • Formula:C14H22O4
  • MW:254.3
  • Appearance:Off-White Solid
  • Purity:98%
Product Name Qty
C75, FAS Inhibitor
5 mg
$625.25
C75, FAS Inhibitor
1 mg
$128.13

Inhibitor of fatty acid synthase (FAS) reducing food intake and body weight in mice. Exhibits irreversible slow-binding biphasic inactivation of FAS. Down regulates neuropeptide Y and Agouti-related protein expression. Has been proposed to activiate CPT-1 activity in liver and adipose tissue, leading to increased fatty acid oxidation and energy production. Shows significant in vivo antitumor activity in human breast cancer cells.Suppresses DNA replication and induces apoptosis. FAS inhibition by C75 leads to dramatic accumulation of the CDK inhibitor p27KIP1 from cytosol to cell nuclei.

More Information
SKU
C-1373
CAS #
191282-48-1
Chemical Name
(2R,3S)-TETRAHYDRO-4-METHYLENE-2-OCTYL-5-OXO-3-FURANCARBOXYLIC ACID
Chemical Formula
C14H22O4
Molecular Weight
254.3
Appearance
Off-White Solid
Purity
98%
Solubility
Soluble in dichloromethane, methanol or DMSO.
Melting Point
142.14 °C
Storage Temp
-20°C. PROTECT FROM LIGHT!
THERAPEUTIC AREA
Oncological Disorders
USE
An inhibitor of FAS.Suppresses DNA replication and induces apoptosis shows significant antitumor activity in human breast cancer cells
MDL NUMBER
MFCD03265452
CHEMACX
X1355404-0
INCHI
InChI=1S/C14H22O4/c1-3-4-5-6-7-8-9-11-12(13(15)16)10(2)14(17)18-11/h11-12H,2-9H2,1H3,(H,15,16)/t11-,12+/m1/s1
SMILES
CCCCCCCC[C@@H]1[C@H](C(=C)C(=O)O1)C(=O)O
Handling
Store in Tightly Sealed Vial
Certificate of Analysis 1
GHS PICTOGRAMS
Handling Store in Tightly Sealed Vial
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