Calcitriol

SKU
C-1026
  • CAS:32222-06-3
  • Formula:C27H44O3
  • MW:416.64 Da
  • Appearance:Colorless lyophilized solid
  • Purity:>99%

2

1

0

Hazardous
Product Name Qty
Calcitriol
1 mg
$749.99
Calcitriol
100 ug
$189.99

Description

Calcitriol is a form of vitamin D3 notable for its physiological activity and ability to easily penetrate cells within the body. Like other analogs of vitamin D, it binds to the cellular vitamin D receptor (VDR). Calcitriol is synthesized predominantly in the kidney via the hydroxylation of calcifediol in response to low levels of calcium or phosphate. This form of vitamin D is responsible for regulating calcium homeostasis in the human body. Calcitriol simultaneously promotes release of stored calcium by the skeletal system while inducing absorption of the mineral by the gastrointestinal system and reabsorption by the kidneys. Remineralization of bone is promoted by this vitamin via absorption of magnesium and phosphate ions. Fatty acid synthesis is also promoted by calcitriol.

Applications

In clinical medicine, calcitriol may be given orally or intravenously as an intervention for hypocalcemia, osteoporosis or secondary hyperparathyroidism. Considerable research has also been conducted on its anti-cancer effects. Calcitriol's identified mechanisms of action against tumors include inducing apoptosis, inhibiting inflammation within tumors and promoting cell differentiation.

More Information
Alternate Name/Synonyms
Rocaltrol; Calcijex; Topitriol; Dihydroxycholecalciferol; Calcitriolum; Dihydroxyvitamin D3
SKU
C-1026
CAS #
32222-06-3
Chemical Name
(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
Chemical Formula
C27H44O3
Molecular Weight
416.64 Da
Appearance
Colorless lyophilized solid
Purity
>99%
Solubility
Soluble in DMSO (25 mg/mL); or Ethanol (25 mg/mL)
Melting Point
111.1-115 °C
Preparation
N/A
Storage Temp
-20°C, desiccated
THERAPEUTIC AREA
Hypocalcaemia, osteoporosis, nutritional disorders
USE
For laboratory and research purpose only. Calcitriol has been used in an ointment for the treatment of psoriasis. Calcitriol has also been given by mouth for the treatment of psoriasis and psoriatic arthritis. Research on the noncalcemic actions of calcitriol and other VDR-ligand analogs and their possible therapeutic applications has been reviewed.
Merck Index
N/A
MDL NUMBER
MFCD00867079
CHEMACX
X1000636-1
INCHI
InChI=1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/t18-,22-,23-,24+,25+,27-/m1/s1
SMILES
C[C@H](CCCC(C)(C)O)[C@H]1CC[C@@H]2[C@@]1(CCCC2=CC=C3C[C@H](C[C@@H](C3=C)O)O)C
Peptide sequence
Not Applicable
GHS Pictograms
3,4
RTECS
FZ4645000
UN #'S
UN 2811
PACKING GROUP
I
HAZARD CLASS
Not Applicable
Handling
Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Use with local exhaust ventilation.
msds 1
/media/upload/pdf/C-1026, Calcitriol, SDS, diamond format.pdf
Certificate of Analysis 1
/media/upload/pdf/C-1026, J1410C.pdf
Certificate of Analysis 2
/media/upload/pdf/C-1026, G1117H.pdf
Certificate of Analysis 3
/media/upload/pdf/C-1026, G1117G.pdf
Spec
GHS PICTOGRAMS
Handling Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Use with local exhaust ventilation.
UN #'S UN 2811
Packing Group I
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