Calcitriol is a form of vitamin D3 notable for its physiological activity and ability to easily penetrate cells within the body. Like other analogs of vitamin D, it binds to the cellular vitamin D receptor (VDR). Calcitriol is synthesized predominantly in the kidney via the hydroxylation of calcifediol in response to low levels of calcium or phosphate. This form of vitamin D is responsible for regulating calcium homeostasis in the human body. Calcitriol simultaneously promotes release of stored calcium by the skeletal system while inducing absorption of the mineral by the gastrointestinal system and reabsorption by the kidneys. Remineralization of bone is promoted by this vitamin via absorption of magnesium and phosphate ions. Fatty acid synthesis is also promoted by calcitriol.
In clinical medicine, calcitriol may be given orally or intravenously as an intervention for hypocalcemia, osteoporosis or secondary hyperparathyroidism. Considerable research has also been conducted on its anti-cancer effects. Calcitriol's identified mechanisms of action against tumors include inducing apoptosis, inhibiting inflammation within tumors and promoting cell differentiation.
|Handling||Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Use with local exhaust ventilation.|
|UN #'S||UN 2811|