Calpain Inhibitor I, MG-101

SKU
P-1153
  • CAS:110044-82-1
  • Formula:C20H37N3O4
  • MW:383.5 Da
  • Appearance:White powder
  • Purity:≥95% by HPLC

Starting at $108.21

Product Name Qty
Calpain Inhibitor I
5 mg
$108.21
Calpain Inhibitor I
25 mg
$353.11

Calpain Inhibitor I  is Cell-permeable, peptide aldehyde inhibitor of calpain I (Ki=190nM), calpain II (C-1259)(Ki=150nM), cathepsin B, cathepsin L (Ki=0.5nM) and other neutral cysteine proteases. Inhibits cell cycle progression at G1/S and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation.

Calpain Inhibitor I also stimulates HMG-CoA synthase transcription by inhibiting degradation of active SREBP-1 (sterol regulatory element-binding protein 1). Protects against neuronal damage caused by hypoxia and ischemia. Inhibits apoptosis in thymocytes and metamyelocytes. Also prevents nitric oxide production by activated macrophages by interfering with the transcription of inducible nitric oxide synthase (iNOS; NOS II).

Calpain Inhibitor I inhibits proteolytic degradation of IκBα and IκBß in RAW macrophages induced with LPS. It also prolong association of MHC class I molecules with the transporters associated with antigen processing.

More Information
Alternate Name/Synonyms
ALLN; Ac-LLnL-CHO; MG-101; N-Acetyl-Leu-Leu-Norleu-al; N-Acetyl-L-leucyl-L-leucyl-L-norleucinal
SKU
P-1153
CAS #
110044-82-1
Chemical Name
(2S)-2-acetamido-4-methyl-N-[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxohexan-2-yl]amino]pentan-2-yl]pentanamide
Chemical Formula
C20H37N3O4
Molecular Weight
383.5 Da
Appearance
White powder
Purity
≥95% by HPLC
Solubility
DMSO (25 mg/mL) or Ethanol (25 mg/mL)
Storage Temp
-20°C, Store in Tightly Sealed Vial. Protect from Light. Protect from Moisture.
THERAPEUTIC AREA
Not Available
USE
Calpain Inhibitor reversibly blocks the calcium-dependent neutral cysteine protease calpain I and neutral cysteine proteases and proteasome (Ki = 6 μM). It inhibits apoptosis in thymocytes and metamyelocytes. It also inhibits cell cycle progression at the G1/S border and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation. Calpain Inhibitor I inhibits the proteolysis of IκBα and IκBβ by the ubiquitin-proteasome complex. Furthermore, it protects against neuronal damage caused by hypoxia and ischemia. Calpain Inhibitor I also prevents nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. It has been implicated in various cellular processes, including cell proliferation, apoptosis, and cell differentiation.
Handling
Ensure adequate ventilation. Wear personal protective equipment. Avoid contact with skin and eyes. Do not breathe dust. Do not breathe vapors or spray mist. Avoid dust formation.
Citations
α-Actinin-4/FSGS1 is required for Arp2/3-dependent actin assembly at the adherens junction Vivian W. Tang and William M. Brieher J. Cell Biol., Jan 2012; 196: 115 - 130.
Citations_Hyperlink
http://jcb.rupress.org/cgi/reprint/196/1/115
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
HandlingEnsure adequate ventilation. Wear personal protective equipment. Avoid contact with skin and eyes. Do not breathe dust. Do not breathe vapors or spray mist. Avoid dust formation.
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