Calpain Inhibitor II

SKU
C-1259
  • CAS:110115-07-6; 136632-32-1
  • Formula:C19H35N3O4S
  • MW:401.6
  • Appearance:White Powder
  • Purity:≥95% by HPLC
Product Name Qty
Calpain Inhibitor II
25 mg
$375.89
Calpain Inhibitor II
5 mg
$96.82

Calpain Inhibitor II is a cell-permeable, peptide aldehyde inhibitor of calpain I (Ki=190nM), calpain II (C-1259)(Ki=150nM), cathepsin B, cathepsin L (Ki=0.5nM) and other neutral cysteine proteases. Calpain Inhibitor II inhibits cell cycle progression at G1/S and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation. Also stimulates HMG-CoA synthase transcription by inhibiting degradation of active SREBP-1 (sterol regulatory element-binding protein 1). Protects against neuronal damage caused by hypoxia and ischemia.

Calpain Inhibitor II inhibits apoptosis in thymocytes and metamyelocytes. Also prevents nitric oxide production by activated macrophages by interfering with the transcription of inducible nitric oxide synthase (iNOS; NOS II). Inhibits proteolytic degradation of IκBα and IκBß in RAW macrophages induced with LPS. It also prolong association of MHC class I molecules with the transporters associated with antigen processing.

More Information
Alternate Name/Synonyms
ALLM, N-Acetyl-L-leucyl-L-leucyl-L-methioninal
SKU
C-1259
CAS #
110115-07-6; 136632-32-1
Chemical Name
N-Acetyl-Leu-Leu-methioninal
Chemical Formula
C19H35N3O4S
Molecular Weight
401.6
Appearance
White Powder
Purity
≥95% by HPLC
Solubility
5 mg/ml soluble in 100% ethanol, methanol or DMSO
Storage Temp
-20°C
Citations
α-Actinin-4/FSGS1 is required for Arp2/3-dependent actin assembly at the adherens junction Vivian W. Tang and William M. Brieher J. Cell Biol., Jan 2012; 196: 115 - 130.
Citations_Hyperlink
http://jcb.rupress.org/cgi/reprint/196/1/115
Certificate of Analysis 1
Certificate of Analysis 2
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