Calphostin C

SKU
C-1451
  • CAS:121263-19-2
  • Formula:C44H38O14
  • MW:790.8
  • Appearance:Dark Red Solid
  • Purity:>95% by HPLC

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Product Name Qty
Calphostin C
1 mg
$759.38
Calphostin C
100 ug
$111.67

Potent and selective inhibitor of protein kinase C (PKC). Inhibits PKC by interacting with the regulatory DAG binding site and phorbol ester binding site. Inhibition is light dependent. It also inhibits Phospholipase D1 and D2. Also reported to induce apoptotic DNA fragmentation and cell death; kills breast cancer cells.

More Information
Alternate Name/Synonyms
UCN 1028 C, PKF 115-384
SKU
C-1451
CAS #
121263-19-2
Chemical Formula
C44H38O14
Molecular Weight
790.8
Appearance
Dark Red Solid
Purity
>95% by HPLC
Solubility
Soluble in ethanol (1 mg/ml), DMSO (1 mg/ml), and DMF (1 mg/ml) Insoluble in water
Stability
N/A
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
The effect of calphostin C, a potent photodependent protein kinase C inhibitor, on the proliferation of glioma cells
MDL NUMBER
MFCD00133155
PubChecm ID
N/A
INCHI
InChI=1S/C44H38O14/c1-20(56-43(50)22-10-8-7-9-11-22)16-25-31-32-26(17-21(2)57-44(51)58-24-14-12-23(45)13-15-24)42(55-6)40(49)34-28(47)19-30(53-4)36(38(32)34)35-29(52-3)18-27(46)33(37(31)35)39(48)41(25)54-5/h7-15,18-21,45,48-49H,16-17H2,1-6H3/t20-,21-/m1/s1
SMILES
C[C@H](CC1=C2C3=C(C(=C(C4=C3C(=C5C2=C(C(=O)C=C5OC)C(=C1OC)O)C(=CC4=O)OC)O)OC)C[C@@H](C)OC(=O)OC6=CC=C(C=C6)O)OC(=O)C7=CC=CC=C7
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