Camostat mesilate

SKU
C-2200
  • CAS:59721-29-8
  • Formula:C20H22N4O5 • CH3SO3H
  • MW:494.5 Da
  • Appearance:Off-white powder
  • Purity:>98% by HPLC

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Starting at $40.00

Product Name Qty
Camostat mesilate
10 mg
$40.00
Camostat mesilate
50 mg
$135.00

Description

A serine protease inhibitor inhibiting plasmin, kallikrein, thrombin as well as trypsin, which attenuates pancreatic fibrosis1 . Reduces weight gain and improves metabolism in obese rodent models2 . In clinical use (in Japan) for pancreatitis3 . Inhibits influenza virus replication in human tracheal epithelial cells4 . Reduces infection of Calu-3 lung cells by SARS-CoV-2 (responsible for COVID-19) via inhibition of the serine protease TMPRSS2 required for viral spike protein priming5 .

Shown to be effective against coronavirus.

  

References

• Camostat mesilate attenuates pancreatic fibrosis via inhibition of monocytes and pancreatic stellate cells activity

• Intestinal serine protease inhibition increases FGF21 and improves metabolism in obese mice

• The Serine Protease Inhibitor Camostat Mesilate Attenuates the Progression of Chronic Kidney Disease through its Antioxidant Effects

• The serine protease inhibitor camostat inhibits influenza virus replication and cytokine production in primary cultures of human tracheal epithelial cells

• SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

  

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
4-(2-(2-(dimethylamino)-2-oxoethoxy)-2-oxoethyl)phenyl 4-guanidinobenzoate, methanesulfonic acid salt; FOY-305; Foipan; Camostat mesylate; Camostat Methanesulfonate
SKU
C-2200
CAS #
59721-29-8
Chemical Name
[4-[2-[2-(dimethylamino)-2-oxoethoxy]-2-oxoethyl]phenyl] 4-(diaminomethylideneamino)benzoate;methanesulfonic acid
Chemical Formula
C20H22N4O5 • CH3SO3H
Molecular Weight
494.5 Da
Appearance
Off-white powder
Purity
>98% by HPLC
Solubility
May be dissolved in DMSO (50 mg/mL) or Water (50 mg/mL)
Storage Temp
Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 1 month.
THERAPEUTIC AREA
Infectious diseases
USE
Protease inhibitor
Handling
Use personal protective equipment as required. Avoid contact with skin, eyes or clothing. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Use with local exhaust ventilation
GHS PICTOGRAMS
Handling Use personal protective equipment as required. Avoid contact with skin, eyes or clothing. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Use with local exhaust ventilation
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