Camptothecin Solution

SKU
C-2215
  • CAS:7689-03-4
  • Formula:C20H16N2O4
  • MW:348.4 Da
  • Appearance:Liquid
  • Purity:≥98% (by TLC)

2

1

0

Hazardous

Starting at $72.99

Product Name Qty
Camptothecin Solution
1 mL
$72.99

Pharmacology:

Camptotecin is a natural product isolated from Camptotheca acuminate. It is an inhibitor of topoisomerase I and binds irreversibly to the topoisomerase I/DNA complex preventing DNA re-ligation and generating permanent double strand breaks. Induces apoptosis in a variety of cell lines and is a potent anti-tumor agent.

Inhibits Tat-mediated transcription of HIV-1. Induces apoptosis in Jurkat, osteosarcoma and hepatoma cells.

 

Product Formulation: 1 mL DMSO solution at 10 mM

 

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
Camptothecine
SKU
C-2215
CAS #
7689-03-4
Chemical Name
(19S)-19-ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione
Chemical Formula
C20H16N2O4
Molecular Weight
348.4 Da
Appearance
Liquid
Purity
≥98% (by TLC)
Solubility
DMSO (5 mg/mL), Ethanol (5 mg/mL)
Melting Point
N/A
Preparation
N/A
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological disorders
USE
Camptothecin Solution selectively inhibits the nuclear enzyme DNA topoisomerase I. It also exhibits intense blue fluorescence when exposed to UV light, which could be useful in optical experiments.
Merck Index
N/A
MDL NUMBER
MFCD00081076
CHEMACX
X1009666-5
INCHI
InChI=1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m0/s1
SMILES
CC[C@@]1(c2cc-3n(c(=O)c2COC1=O)Cc4c3nc5ccccc5c4)O
GHS Pictograms
3,4
RTECS
UQ0492000
UN #'S
UN 1544
PACKING GROUP
III
HAZARD CLASS
Not Applicable
Handling
Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Use with local exhaust ventilation.
Spec
GHS PICTOGRAMS
Handling Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Use with local exhaust ventilation.
UN #'S UN 1544
Packing Group III
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