Camptothecin

SKU
C-1261
  • CAS:7689-03-4
  • Formula:C20H16N2O4
  • MW:348.4 Da
  • Appearance:Pale-yellow powder
  • Purity:≥98%

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Product Name Qty
Camptothecin
250 mg
$180.90
Camptothecin
1 g
$396.45

Description

Camptothecin is an inhibitor of nuclear topoisomerase I. It acts by binding to and trapping the topoisomerase-DNA covalent complex.

Applications

• Topoisomerase I inhibitor

More Information
Alternate Name/Synonyms
Camptothecine; Campathecin; (S)-(+)-Camptothecin; (+)-Camptothecin; d-Camptothecin; 20(S)-Camptothecine
SKU
C-1261
CAS #
7689-03-4
Chemical Name
(19S)-19-ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione
Chemical Formula
C20H16N2O4
Molecular Weight
348.4 Da
Appearance
Pale-yellow powder
Purity
≥98%
Solubility
Soluble in ethanol and methanol
Melting Point
N/A
Preparation
N/A
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
A reversible mitochondrial topoisomerase I inhibitor shown to exhibit anti-tumor activity.
Merck Index
N/A
MDL NUMBER
MFCD00081076
CHEMACX
X1009666-5
INCHI
InChI=1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m0/s1
SMILES
CC[C@@]1(c2cc-3n(c(=O)c2COC1=O)Cc4c3nc5ccccc5c4)O
Peptide sequence
N/A
RTECS
UQ0492000
UN #'S
UN 1544
PACKING GROUP
III
HAZARD CLASS
N/A
Handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols.Further processing of solid materials may result in the formation of combustible dusts. The potential for combustible dust formation should be taken into consideration before additional processing occurs
Citations
Enhancing Drug Accumulation in Saccharomyces cerevisiae by Repression of Pleiotropic Drug Resistance Genes with Chimeric Transcription Repressors Alexander Stepanov, Karin C. Nitiss, Geoffrey Neale, and John L. Nitiss Mol. Pharmacol., Aug 2008; 74: 423 - 431.
Citations_Hyperlink
http://molpharm.aspetjournals.org/cgi/reprint/74/2/423
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
GHS PICTOGRAMS
Handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols.Further processing of solid materials may result in the formation of combustible dusts. The potential for combustible dust formation should be taken into consideration before additional processing occurs
UN #'S UN 1544
Packing Group III
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