Canertinib

SKU
C-2216
  • CAS:289499-45-2
  • Formula:C24H25ClFN5O3 2HCl
  • MW:558.86
  • Appearance:Off-white to pale green Solid
  • Purity:99%

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Product Name Qty
Canertinib
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Canertinib is an irreversible tyrosine kinase inhibitor.It not only inhibits tyrosine phosphorylation but also enhances ubiquitinylation and accelerates endocytosis and subsequent intracellular destruction of ErbB-2 molecules. Canertinib alkylates a cysteine residue specific to ErbB receptors. The degradative pathway of ErbB receptor tyrosine kinases stimulated by tyrosine kinase inhibitors appears to be chaperone mediated, and thus is similar to the pathways activated by the heat shock protein 90 (Hsp90) antagonist geldanamycin and by stress-induced mechanisms.
More Information
SKU
C-2216
CAS #
289499-45-2
Chemical Formula
C24H25ClFN5O3 2HCl
Molecular Weight
558.86
Appearance
Off-white to pale green Solid
Purity
99%
Solubility
DMSO (100 mg/ml)
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
Canertinib is an irreversible EGFR tyrosine kinase inhibitor for the treatment of solid tumors
MDL NUMBER
MFCD09837878
CHEMACX
X1511904-1
INCHI
InChI=1S/C24H25ClFN5O3/c1-2-23(32)30-21-13-17-20(14-22(21)34-9-3-6-31-7-10-33-11-8-31)27-15-28-24(17)29-16-4-5-19(26)18(25)12-16/h2,4-5,12-15H,1,3,6-11H2,(H,30,32)(H,27,28,29)
SMILES
C=CC(=O)Nc1cc2c(cc1OCCCN3CCOCC3)ncnc2Nc4ccc(c(c4)Cl)F
RTECS
UC6316110
Handling
Protect from air and moisture
Handling Protect from air and moisture
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