Cantharidin

SKU
C-1412
  • CAS:56-25-7
  • Formula:C10H12O4
  • MW:196.2 Da
  • Appearance:White powder
  • Purity:>98% by HPLC

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Product Name Qty
Cantharidin, Specific protein phosphatase 2A inhibitor
25 mg
$136.69
Cantharidin, Specific protein phosphatase 2A inhibitor
10 mg
$71.77

Description

Cantharidin is a terpenoid compound produced by blister beetles. It acts as a potent and selective inhibitor of protein phosphatase 2A (PP2A) and inhibits protein phosphatase 1 (PP1) at higher concentrations. Useful in inhibition of PP2A and PP1 during purification of phosphorylated proteins. This inhibitor also weakly suppresses the activity of protein phosphatase 2B (PP2B).

It is known that Cantharidin induces apoptosis in many types of tumor cell. It is reported that it causes down-regulation of CCAT1 related to PI3K/Akt signaling so that inhibits proliferation and metastasis. The toxin is a poisonous vesicant and toxic to some pests.

 

Application

• Inhibitor of protein phosphatase 2A

• Used for anticancer agent

• Component of pesticides

 

References

"Cantharidin: Potent Feeding Deterrent to Insects"

• “The Effects of Cantharidin and Cantharidin Derivates on Tumour Cells”

• “Cantharidin suppresses gastric cancer cell migration/invasion by inhibiting the PI3K/Akt signaling pathway via CCAT1”

 

 Not for human therapeutic use or for medicinal purposes. For research applications only. 

More Information
Alternate Name/Synonyms
Cantharidine; Cantharone; Kantaridin; Kantharidin; Cantharides camphor
SKU
C-1412
CAS #
56-25-7
Chemical Name
(1R,2S,6R,7S)-2,6-dimethyl-4,10-dioxatricyclo[5.2.1.02,6]decane-3,5-dione
Chemical Formula
C10H12O4
Molecular Weight
196.2 Da
Appearance
White powder
Purity
>98% by HPLC
Solubility
Soluble in DMSO (20 mg/ml) or Ethanol (5 mg/ml)
Melting Point
215-217 °C
Storage Temp
-20°C, desiccated
THERAPEUTIC AREA
Not Applicable
USE
Cantharidin appears to have some effect in the topical treatment of cutaneous leishmaniasis in animal models. In addition to topical medical applications, cantharidin and its analogues may have activity against cancer cells. Laboratory studies with cultured tumor cells suggest that this activity may be the result of PP2A inhibition.
MDL NUMBER
MFCD00134968
CHEMACX
X1000733-5
INCHI
InChI=1S/C10H12O4/c1-9-5-3-4-6(13-5)10(9,2)8(12)14-7(9)11/h5-6H,3-4H2,1-2H3/t5-,6+,9+,10-
SMILES
C[C@@]12[C@H]3CC[C@@H]([C@@]1(C(=O)OC2=O)C)O3
RTECS
RN8575000
UN #'S
UN 2811
PACKING GROUP
I
Handling
Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Use with local exhaust ventilation. Noxious vapor/odor. Ensure adequate ventilation, especially in confined areas.
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
GHS PICTOGRAMS
Handling Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Use with local exhaust ventilation. Noxious vapor/odor. Ensure adequate ventilation, especially in confined areas.
UN #'S UN 2811
Packing Group I
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