Capreomycin sulfate
SKU
C-2607
- CAS:1405-37-4
- Formula:C24H42N14O8 • H2SO4
- MW:752.8 Da
- Appearance:White powder
- Purity:≥90%
SDS
CofA
Description
Capreomycin sulfate is a salt of a complex of cyclic pentopeptides isolated from Streptomyces capreolus, first reported in 1962. The sulfate salt is the most commonly accessible formulation of capreomycin and is used for pharmaceutical applications. The complex has two major components, IA and IB, with an exocyclic lysine residue and two minor delysinyl components, IIA and IIB. Capreomycin acts by binding to the 23S ribosomal subunit, disrupting protein synthesis.
Applications
Capreomycin is a potent antibiotic with activity against mycobateria, Gram-positive and Gram-negative organisms. It is cytotoxic to M. tuberculosis, more effective when combined with aminoglycoside antibiotics.
More Information
Alternate Name/Synonyms
Capreomycin sulfate from Streptomyces capreolus
SKU
C-2607
CAS #
1405-37-4
Chemical Name
(2S)-2,5-diamino-N-[[(2S,5S,8Z,11S,15S)-15-amino-11-(2-amino-1,4,5,6-tetrahydropyrimidin-6-yl)-8-[(carbamoylamino)methylidene]-2-(hydroxymethyl)-3,6,9,12,16-pentaoxo-1,4,7,10,13-pentazacyclohexadec-5-yl]methyl]pentanamide;sulfuric acid
Chemical Formula
C24H42N14O8 • H2SO4
Molecular Weight
752.8 Da
Appearance
White powder
Purity
≥90%
Solubility
Water: 50 mg/mL (we do not recommend storing the aqueous solution for more than 1 day)
Stability
≥2 years
Storage Temp
-20°C
THERAPEUTIC AREA
Infectious Diseases
USE
Capreomycin is a cyclic peptide antibiotic that is often grouped with aminoglycosides. It is a second line antibiotic and is used to study multidrug-resistant tuberculosis.
MDL NUMBER
MFCD00079032
INCHI
InChI=1S/C24H42N14O8.H2O4S/c25-4-1-2-10(26)17(40)32-7-13-19(42)34-14(8-33-24(29)46)20(43)38-16(12-3-5-30-23(28)37-12)22(45)31-6-11(27)18(41)36-15(9-39)21(44)35-13;1-5(2,3)4/h8,10-13,15-16,39H,1-7,9,25-27H2,(H,31,45)(H,32,40)(H,34,42)(H,35,44)(H,36,41
SMILES
O=C(NC[C@H](C(N/C(C(N[C@@H](C1NC(N)=NCC1)C(NC[C@H]2N)=O)=O)=C\NC(N)=O)=O)NC([C@H](CO)NC2=O)=O)[C@@H](N)CCCN.O=S(O)(O)=O
Handling
Avoid breathing dust/fume/gas/mist/vapours/spray. Avoid prolonged or repeated exposure. Handle in accordance with good industrial hygiene and safety practice
Certificate of Analysis 1
| GHS PICTOGRAMS |
|
|---|---|
| Handling | Avoid breathing dust/fume/gas/mist/vapours/spray. Avoid prolonged or repeated exposure. Handle in accordance with good industrial hygiene and safety practice |
We found other products you might like!
