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Capreomycin sulfate

SKU
C-2607
  • CAS:1405-37-4
  • Formula:C24H42N14O8 • H2SO4
  • MW:752.8 Da
  • Appearance:White powder
  • Purity:≥90%
Product Name Qty
Capreomycin sulfate
1 g
$125.20
Capreomycin sulfate
5 g
$443.46
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Description

Capreomycin sulfate is a salt of a complex of cyclic pentopeptides isolated from Streptomyces capreolus, first reported in 1962. It is the most commonly accessible formulation of capreomycin which is composed of capreomycins IA, IB, IIA and IIB. It is known that the sulfate salt is often grouped with aminoglycosides and disrupts protein synthesis by inhibiting normal ribosomal functions. Capreomycin is more effective against M. tuberculosis when it combined with aminoglycoside antibiotics.

 

Applications

• Antibiotic with activity against mycobacteria, Gram-positive and Gram-negative organisms

• Study for bacterial ribosomal subunit interactions and translocation processes during protein synthesis

• Study for multidrug-resistant tuberculosis

 

Reference

• “Chemical and Physical Characterization of Capreomycin” 

 

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
Capreomycin sulfate from Streptomyces capreolus
SKU
C-2607
CAS #
1405-37-4
Chemical Name
(2S)-2,5-diamino-N-[[(2S,5S,8Z,11S,15S)-15-amino-11-(2-amino-1,4,5,6-tetrahydropyrimidin-6-yl)-8-[(carbamoylamino)methylidene]-2-(hydroxymethyl)-3,6,9,12,16-pentaoxo-1,4,7,10,13-pentazacyclohexadec-5-yl]methyl]pentanamide;sulfuric acid
Chemical Formula
C24H42N14O8 • H2SO4
Molecular Weight
752.8 Da
Appearance
White powder
Purity
≥90%
Solubility
Water: 50 mg/mL (we do not recommend storing the aqueous solution for more than 1 day)
Stability
≥2 years
Storage Temp
-20°C
THERAPEUTIC AREA
Infectious Diseases
USE
Capreomycin is a cyclic peptide antibiotic that is often grouped with aminoglycosides. It is a second line antibiotic and is used to study multidrug-resistant tuberculosis.
MDL NUMBER
MFCD00079032
INCHI
InChI=1S/C24H42N14O8.H2O4S/c25-4-1-2-10(26)17(40)32-7-13-19(42)34-14(8-33-24(29)46)20(43)38-16(12-3-5-30-23(28)37-12)22(45)31-6-11(27)18(41)36-15(9-39)21(44)35-13;1-5(2,3)4/h8,10-13,15-16,39H,1-7,9,25-27H2,(H,31,45)(H,32,40)(H,34,42)(H,35,44)(H,36,41
SMILES
O=C(NC[C@H](C(N/C(C(N[C@@H](C1NC(N)=NCC1)C(NC[C@H]2N)=O)=O)=C\NC(N)=O)=O)NC([C@H](CO)NC2=O)=O)[C@@H](N)CCCN.O=S(O)(O)=O
Handling
Avoid breathing dust/fume/gas/mist/vapours/spray. Avoid prolonged or repeated exposure. Handle in accordance with good industrial hygiene and safety practice
Certificate of Analysis 1
C-2607, J1251.pdf
GHS PICTOGRAMS
HandlingAvoid breathing dust/fume/gas/mist/vapours/spray. Avoid prolonged or repeated exposure. Handle in accordance with good industrial hygiene and safety practice
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