Carfilzomib

SKU
C-2857
  • CAS:868540-17-4
  • Formula:C40H57N5O7
  • MW:719.9
  • Appearance:White powder
  • Purity:>98% (HPLC)
Product Name Qty
Carfilzomib
5 mg
$59.51

A potent and irreversible proteasome inhibitor. Synthetic analog of the microbial product epoxomcin. Compared to bortezomib it displays equal potency but greater selectivity for the chymotrypsin-like activity of the proteasome. In cell culture it is more cytotoxic than bortezomib and hematologic tumor cells exhibit greater sensitivity than solid tumor cells. Treatment of cells with carfilzomib results in the accumulation of proteasome substrates and induction of cell cycle arrest and/or apoptosis. Effective against multiple myeloma. Active in vivo.

References:

1. MK Bennett and CJ Kirk Curr. Opin. Drug Disc. Dev. 2008 11:616

2. M Hanada et al. J. Antibiot. (Tokyo) 1992 45:1746

3. SD Demo et al. Cancer Res. 2007 67:6383 4. DJ Kuhn et al. Blood 2007 110:3281

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
(αS)-α-[[2-(4-morpholinyl)acetyl]amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-L-Phenylalaninamide; PR-171
SKU
C-2857
CAS #
868540-17-4
Chemical Formula
C40H57N5O7
Molecular Weight
719.9
Appearance
White powder
Purity
>98% (HPLC)
Solubility
May be dissolved in DMSO (80 mg/ml); or ethanol (25 mg/ml)
Stability
N/A
Storage Temp
-20°C
Promo text for AGS discount
N/A
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