Caspase-13 Substrate LEED-AFC

SKU
C-2234
  • Formula:C32H38F3N5O13
  • MW:757.66
  • Appearance:Liquid
  • Purity:98% by HPLC
Product Name Qty
Caspase-13 Substrate LEED-AFC
200 assays
$290.47
Caspase-13 Substrate LEED-AFC
1000 assays
$620.78

Ready-to-use fluorometric substrate for caspase-13 and related caspases that recognize the amino acid sequence LEED. Caspase-13 and related caspase activity can be quantified by fluorescent detection of free AFC after cleavage from the peptide substrate LEED-AFC at Ex. = 400 nm and Em. = 505 nm, using a fluorometer or multi-well fluorescence plate reader. Alternatively, a shift in fluorescence from blue to green upon cleavage can be visualized using a hand-held long-UV lamp.

More Information
Alternate Name/Synonyms
Ac-LEED-AFC, Caspase-13 Substrate, Fluorogenic
SKU
C-2234
Chemical Name
Ac-LEED-AFC, Caspase-13 Substrate, Fluorogenic
Chemical Formula
C32H38F3N5O13
Molecular Weight
757.66
Appearance
Liquid
Purity
98% by HPLC
Storage Temp
-20°C
THERAPEUTIC AREA
Not Available
USE
Fluorogenic substrate for caspase 13
MDL NUMBER
MFCD03452816
CHEMACX
X1340858-5
INCHI
InChI=1S/C32H38F3N5O13/c1-14(2)10-21(36-15(3)41)31(52)39-19(6-8-24(42)43)28(49)38-20(7-9-25(44)45)29(50)40-22(13-26(46)47)30(51)37-16-4-5-17-18(32(33,34)35)12-27(48)53-23(17)11-16/h4-5,11-12,14,19-22H,6-10,13H2,1-3H3,(H,36,41)(H,37,51)(H,38,49)(H,39,52)(H,40,50)(H,42,43)(H,44,45)(H,46,47)/t19-,20-,21-,22-/m0/s1
SMILES
CC(C)C[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)Nc1ccc2c(cc(=O)oc2c1)C(F)(F)F)NC(=O)C
Peptide sequence
AC-LEU-GLU-GLU-ASP-AFC
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Protect from light and moisture
GHS PICTOGRAMS
Handling Protect from light and moisture
UN #'S Not Applicable
Packing Group Not Applicable
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