Caspase-3 Substrate DEVD-pNA

SKU
C-2240
  • Formula:C26H34N6O13
  • MW:638.58
  • Appearance:Liquid
  • Purity:98% by HPLC
Product Name Qty
Caspase-3 Substrate DEVD-pNA
200 assays
$290.47
Caspase-3 Substrate DEVD-pNA
1000 assays
$620.78

Ready-to-use colorimetric substrate for CPP32/caspase-3 and related caspases that recognize the amino acid sequence DEVD. The sequence DEVD is based on caspase-3 cleavage site in poly (ADP-ribose) polymerase (PARP). CPP32 and related caspase activity can be quantified by spectrophotometric detection of free pNA (l = 400 nm) after cleavage from the peptide substrate DEVD-pNA, using a spectrophotometer or multi-well plate reader. The ready-to-use caspase substrate provides an economic alternative for researchers who perform large amounts of caspase assays.

More Information
Alternate Name/Synonyms
Ac-DEVD-pNA, Caspase-3 Substrate, Colorimetric
SKU
C-2240
Chemical Name
Ac-DEVD-pNA, Caspase-3 Substrate, Colorimetric
Chemical Formula
C26H34N6O13
Molecular Weight
638.58
Appearance
Liquid
Purity
98% by HPLC
Storage Temp
-20°C
THERAPEUTIC AREA
Not Available
USE
A colorimetric substrate for caspase-3 (CPP32) and related cysteine proteases
MDL NUMBER
MFCD00792707
CHEMACX
X1218447-3
INCHI
InChI=1S/C26H34N6O13/c1-12(2)22(26(43)30-18(11-21(38)39)24(41)28-14-4-6-15(7-5-14)32(44)45)31-23(40)16(8-9-19(34)35)29-25(42)17(10-20(36)37)27-13(3)33/h4-7,12,16-18,22H,8-11H2,1-H3,(H,27,33)(H,28,41)(H,29,42)(H,30,43)(H,31,40)(H,34,35)(H,36,37)(H,38,39)
SMILES
CC(C)C(C(=O)NC(CC(=O)O)C(=O)NC1=CC=C(C=C1)[N+](=O)[O-])NC(=O)C(CCC(=O)O)NC(=O)C(CC(=O)O)NC(=O)C
Peptide sequence
AC-ASP-GLU-VAL-ASP-PNA
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Protect from light and moisture
GHS PICTOGRAMS
HandlingProtect from light and moisture
UN #'SNot Applicable
Packing GroupNot Applicable
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