Caspase-5 Inhibitor Z-WEHD-FMK

SKU
C-2247
  • Formula:C37H42FN7O11
  • MW:763.78 Da
  • Appearance:Liquid
  • Purity:>99% by HPLC
Product Name Qty
Caspase-5 Inhibitor Z-WEHD-FMK
100 l (2mM)
$153.00
Caspase-5 Inhibitor Z-WEHD-FMK
20 l (10mM)
$153.00

Description

A synthetic peptide that irreversibly inhibits caspase-5 and related caspase activity. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).

Specifications

• Peptide Sequence: Z-Trp-Glu(OMe)-His-Asp(OMe)-FMK
• Formulation: 1100-100 in DMSO (2 mM); 1100-20C in DMSO (10 mM)

More Information
Alternate Name/Synonyms
Z-WEHD-FMK, Caspase-5 Inhibitor (fluoromethylketone)
SKU
C-2247
Chemical Name
Z-WEHD-FMK, Caspase-5 Inhibitor (fluoromethylketone)
Chemical Formula
C37H42FN7O11
Molecular Weight
763.78 Da
Appearance
Liquid
Purity
>99% by HPLC
Storage Temp
-20°C
USE
We recommend using 1000X dilutions for inhibiting caspase-3 activity in Jurkat cell culture (e.g., Add 1 µl to 1 mL of culture medium). The optimal doses may vary for different cells and culture conditions.
MDL NUMBER
MFCD01862606
CHEMACX
X1486542-0
INCHI
InChI=1S/C37H42FN7O10/c1-53-32(47)13-12-27(34(49)44-30(15-24-19-39-21-41-24)36(51)43-28(31(46)17-38)16-33(48)54-2)42-35(50)29(14-23-18-40-26-11-7-6-10-25(23)26)45-37(52)55-20-22-8-4-3-5-9-22/h3-11,18-19,21,27-30,40H,12-17,20H2,1-H3,(H,39,41)(H,42,50)(H,43,51)(H,44,49)(H,45,52)
SMILES
COC(=O)CCC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)OCC4=CC=CC=C4
Peptide sequence
Z-TRP-GLU(OME)-HIS-ASP(OME)-FMK
Handling
Protect from light and moisture. Keep away from sources of ignition—no smoking. Take measures to prevent the build up electrostatic charge.
Certificate of Analysis 1
HandlingProtect from light and moisture. Keep away from sources of ignition—no smoking. Take measures to prevent the build up electrostatic charge.
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