Caspase-8 Substrate IETD-pNA

SKU
C-2252
  • Formula:C27H38N6O12
  • MW:638.6
  • Appearance:Liquid
  • Purity:95% by HPLC
Product Name Qty
Caspase-8 Substrate IETD-pNA
200 assays
$290.47
Caspase-8 Substrate IETD-pNA
1000 assays
$620.78

Ready-to-use colorimetric substrate for FLICE/caspase-8 and related caspases that recognize the amino acid sequence IETD. The sequence IETD is based on caspase-8 cleavage site in CPP32/Caspase-3 proenzyme. FLICE and related caspase activity can be quantified by spectrophotometric detection of free pNA (l= 400 nm) after cleavage from the peptide substrate IETD-pNA, using a spectrophotometer or multi-well plate reader.

More Information
Alternate Name/Synonyms
Ac-IETD-pNA, Caspase-8 Substrate, Colorimetric
SKU
C-2252
Chemical Name
Ac-IETD-pNA, Caspase-8 Substrate, Colorimetric
Chemical Formula
C27H38N6O12
Molecular Weight
638.6
Appearance
Liquid
Purity
95% by HPLC
Storage Temp
-20°C
THERAPEUTIC AREA
Not Available
USE
Colorimetric substrate for FLICE/caspase-8 and related caspases that recognize the amino acid sequence IETD
MDL NUMBER
MFCD01318840
CHEMACX
X1206333-3
INCHI
InChI=1S/C27H38N6O12/c1-5-13(2)22(28-15(4)35)26(42)30-18(10-11-20(36)37)24(40)32-23(14(3)34)27(43)31-19(12-21(38)39)25(41)29-16-6-8-17(9-7-16)33(44)45/h6-9,13-14,18-19,22-23,34H,5,10-12H2,1-4H3,(H,28,35)(H,29,41)(H,30,42)(H,31,43)(H,32,40)(H,36,37)(H,38,39)/t13-,14+,18-,19-,22-,23-/m0/s1
SMILES
CC[C@H](C)[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)Nc1ccc(cc1)[N+](=O)[O-])NC(=O)C
Peptide sequence
AC-ILE-GLU-THR-ASP-PARANITROANILIDE
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Protect from light and moisture
GHS PICTOGRAMS
Handling Protect from light and moisture
UN #'S Not Applicable
Packing Group Not Applicable
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