CBR-5884, PHGDH / serine biosynthesis inhibitor
SKU
C-2901
- CAS:681159-27-3
- Formula:C14H12N2O4S2
SDS
CofA
CBR-5884 is a potent and selective inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), IC50=33 μM. The action of PHGDH is the first committed step of serine biosynthesis and certain cancer cells overexpress PHGDH. CBR-5884 inhibits serine biosynthesis in cells with no effect on two other dehydrogenases, lactate dehydrogenase, and MDH1 and without general cytotoxic effects up to 40 μM. CBR-5884 is selectively toxic to tumor cells with high serine synthesis activity. A novel tool for selective inhibition of serine biosynthesis in cells which also provides further proof that PHGDH is a viable target for the development of novel anticancer agents.
More Information
Alternate Name/Synonyms
PHGDH / serine biosynthesis inhibitor
SKU
C-2901
CAS #
681159-27-3
Chemical Name
Ethyl-5-(furan-carboxamido)-3-methyl-4-thiocyanatothiophene-2-carboxylate
Chemical Formula
C14H12N2O4S2
Hazard Image
Yes