CDK1/2 Inhibitor III

SKU
C-1447
  • Formula:C15H13F2N7O2S2
  • MW:425.4
  • Appearance:White to off-white Solid
  • Purity:95% by HPLC

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Product Name Qty
CDK1/2 Inhibitor III
1 mg
$212.19
Cell permeable triazolo-diamine compound;displays anti-proliferative properties inhuman cancer cells (IC50=20nM, 35nM and 92nM in HCT-116, HeLa, and A375 cells). Acts as a highly potent, ATP-competitive inhibitor of CDK1/cyclin B and CDK2/cyclin A (IC=600pM and 500pM) with selectivity over VEGF-R2 and GSK-3 (IC=32nM and 140nM).
More Information
Alternate Name/Synonyms
5-Amino-3-((4-(aminosulfonyl)phenyl)amino)-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide
SKU
C-1447
Chemical Name
5-Amino-3-((4-(aminosulfonyl)phenyl)amino)-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide
Chemical Formula
C15H13F2N7O2S2
Molecular Weight
425.4
Appearance
White to off-white Solid
Purity
95% by HPLC
Solubility
Soluble in DMSO (10mg/ml).
Stability
N/A
Storage Temp
-20°C
THERAPEUTIC AREA
Not Available
USE
Not Available
MDL NUMBER
MFCD09264159
CHEMACX
Not Applicable
INCHI
InChI=1S/C15H13F2N7O2S2/c16-10-2-1-3-11(17)12(10)21-15(27)24-13(18)22-14(23-24)20-8-4-6-9(7-5-8)28(19,25)26/h1-7H,(H,21,27)(H2,19,25,26)(H3,18,20,22,23)
SMILES
c1cc(c(c(c1)F)NC(=S)n2c(nc(n2)Nc3ccc(cc3)S(=O)(=O)N)N)F
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Store in Tightly Sealed Vial Protect from Light
E-Guides
N/A
Blog Post
N/A
Certificate of Analysis 1
Promo text for AGS discount
N/A
GHS PICTOGRAMS
Handling Store in Tightly Sealed Vial Protect from Light
UN #'S Not Applicable
Packing Group Not Applicable
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