Cefotaxime Sodium Salt

SKU
C-1463
  • CAS:64485-93-4
  • Formula:C16H16N5O7S2•Na
  • MW:477.45 Da
  • Appearance:White to off-white crystalline powder
  • Purity:≥97%

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Product Name Qty
Cefotaxime Sodium Salt
50 g
$1,727.36
Cefotaxime Sodium Salt
1 g
$61.81
Cefotaxime Sodium Salt
5 g
$299.87
Cefotaxime Sodium Salt
25 g
$919.46

Description:

Cefotaxime sodium salt is a potent cephalosporin antibiotic that inhibits bacterial cell wall synthesis by binding to PBPs (penicillin-binding proteins). This binding action inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, resulting in lysis of bacteria. Cefotaxime was discovered in 1976 and is now listed on the World Health Organization's List of Essential Medicines.

Cefotaxime sodium salt is effective against both Gram-negative and Gram-positive bacteria and is resistant to β -lactamase. Cefotaxime also prevents division of cyanobacteria and lower plant organelles such as the photosynthetic components of Glaucophtyes and the chloroplasts of bryophytes.

 

Applications:

Cefotaxime has been used to treat joint infections, inflammatory diseases, meningitis, pneumonia, sepsis, urinary tract infections, gonorrhea, and cellulitis.

 

Specifications:

• EC Number: 264-915-9
• Antibiotic Activity Spectrum: Gram-negative and Gram-positive bacteria
• Mode of Action: Interferes with cell wall synthesis

More Information
Alternate Name/Synonyms
Tolycar; Pretor; Cefotax; Claforan; Ralopar; Tolycor; Zariviz
SKU
C-1463
CAS #
64485-93-4
Chemical Name
sodium;(6R,7R)-3-(acetyloxymethyl)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
Chemical Formula
C16H16N5O7S2•Na
Molecular Weight
477.45 Da
Appearance
White to off-white crystalline powder
Purity
≥97%
Solubility
Clear solution in H2O
Melting Point
163 °C
Preparation
N/A
Storage Temp
+4°C, desiccated
THERAPEUTIC AREA
Infectious diseases
USE
Cefotaxime Sodium Salt is a third generation Cephalosporin β-lactamase resistant antibiotic with efficacy in prohibition of gram-positive and gram-negative bacterial cell wall synthesis. The compound has demonstrated greater activity than other available first- and second-generation cephalosporins against Enterobacteriaceae. More active than older cephalosporins against Pseudomonas aeruginosa and Acinetobacter spp., but most strains are still considered resistant. Also active against some gram-negative bacilli that are resistant to aminoglycosides, including amikacin (sc-278692). Activity comparable with other cephalosporins against gram-positive cocci, except staphylococci and enterococci, which are resistant. In combination with penicillins or aminoglycosides may be synergistic against selected gram-negative bacilli.
Merck Index
N/A
MDL NUMBER
MFCD00079073
CHEMACX
X1004218-9
PubChecm ID
24892923
INCHI
AZZMGZXNTDTSME-JUZDKLSSSA-M
SMILES
CC(=O)OCC1=C(N2[C@@H]([C@@H](C2=O)NC(=O)/C(=NOC)/c3csc(n3)N)SC1)C(=O)[O-].[Na+]
RTECS
XI0250000
Handling
Avoid contact with skin, eyes or clothing. Wash contaminated clothing before reuse. Do not eat, drink or smoke when using this product. Use personal protective equipment as required. Do not breathe dust/fume/gas/mist/vapors/spray. Use with local exhaust ventilation. Corrosive hazard. Wear protective gloves/clothing and eye/face protection.
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
GHS PICTOGRAMS
Handling Avoid contact with skin, eyes or clothing. Wash contaminated clothing before reuse. Do not eat, drink or smoke when using this product. Use personal protective equipment as required. Do not breathe dust/fume/gas/mist/vapors/spray. Use with local exhaust ventilation. Corrosive hazard. Wear protective gloves/clothing and eye/face protection.
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