Cefpodoxime (free acid) is a metabolite of Cefpodoxime proxetil and a third generation cephalosporin anti-bacterial that is active against both Gram-positive and negative bacteria. Its effect is to inhibit synthesis of bacterial cell wall. Cephalosporins are a type of β-lactam antibiotic that prevents the formation of peptidoglycan cross-links within bacterial cell walls by targeting penicillin-binding proteins.
It is stable towards the most commonly found plasmid-mediated β-lactamases. The in vitro inhibitory activity of it is little affected by the addition of plasma serum or the type of testing medium used; however, increasing the inocula size more than 106 cfu/ml reduced the potency of the drug against β-lactamase producing strains of Enterobacteriaceae. It is reported that Cefpodoxime proxetil has a postantibiotic effect of up to 2 hours against Gram-positive species, although it was without effect against Gram-negative species.
• Antibiotic for gram-positive and gram-negative bacteria
• Antimicrobial susceptibility test
Not for human therapeutic use or for medicinal purposes. For research applications only.
|Handling||Avoid contact with skin, eyes, and personal clothing. Wash hands thoroughly after handling. Avoid breathing fumes. Use only with adequate ventilation. Wear suitable protective clothing, gloves, and eye/face protection. Keep away from sources of ignition. Minimize dust generation and accumulation. Keep container tightly closed. Open and handle container with care. Do not eat, drink, or smoke while handling.|
|UN #'S||Not Applicable|
|Packing Group||Not Applicable|