Celastrol (Tripterin)

SKU
C-2262
  • CAS:34157-83-0
  • Formula:C29H38O4
  • MW:450.61 Da
  • Appearance:Red powder
  • Purity:≥99%

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Product Name Qty
Celastrol
5 mg
$60.00
Celastrol
25 mg
$235.00
Celastrol
100 mg
$800.00

Description

Celastrol (also known as Tripterin) is a cell-permeable proteasome inhibitor. Acts as an antioxidant, anti-inflammatory and immunosuppressive agent. Suppresses LPS-induced cytokine release in macrophages and monocytes (IC= 40 nM for IL-1 and IL-1, 80 nM for IL-6, 110 nM for prostaglandin E2 and 210 nM for IL-8 and TNF). Suppresses nitric oxide (NO) production (IC= 230 nM) and LPS-induced NF-B activation (IC= 270 nM).Inhibits chymotrypsin-like activity of 20S proteasome (IC= 2.5 M) and lipid peroxidation induced by ADP and Fe in rat liver mitochondria (IC= 7 M).

Isolated from Tripterygium wilfordii.

 

More Information
Alternate Name/Synonyms
Celastrol; Tripterin; Tripterine; 3-hydroxy-9β,13α-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid
SKU
C-2262
CAS #
34157-83-0
Chemical Name
(2R,4aS,6aR,6aS,14aS,14bR)-10-hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylic acid
Chemical Formula
C29H38O4
Molecular Weight
450.61 Da
Appearance
Red powder
Purity
≥99%
Solubility
Methanol: Clear red solution at 10 mg/mL
Melting Point
215-218°C
Storage Temp
-20°C
THERAPEUTIC AREA
Neurological Disorders
USE
Cell-permeable proteasome inhibitor. Potent antioxidant and anti-inflammatory drug. Possible treatment for Alzheimer's disease.
MDL NUMBER
MFCD03424073
CHEMACX
X1463240-3
INCHI
InChI=1S/C29H38O4/c1-17-18-7-8-21-27(4,19(18)15-20(30)23(17)31)12-14-29(6)22-16-26(3,24(32)33)10-9-25(22,2)11-13-28(21,29)5/h7-8,15,22,31H,9-14,16H2,1-6H3,(H,32,33)/t22-,25-,26-,27+,28-,29+/m1/s1
SMILES
CC1=C(C(=O)C=C2C1=CC=C3[C@]2(CC[C@@]4([C@@]3(CC[C@@]5([C@H]4C[C@](CC5)(C)C(=O)O)C)C)C)C)O
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
UN 2811
PACKING GROUP
III
HAZARD CLASS
Not Applicable
Handling
Avoid breathing dust/fume/gas/mist/vapors/spray. Avoid prolonged or repeated exposure. Keep container tightly closed. Store in accordance with information listed on the product insert.
GHS PICTOGRAMS
Handling Avoid breathing dust/fume/gas/mist/vapors/spray. Avoid prolonged or repeated exposure. Keep container tightly closed. Store in accordance with information listed on the product insert.
UN #'S UN 2811
Packing Group III
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