Carbenicillin Disodium Salt

SKU
C-1385
  • CAS:4800-94-6
  • Formula:C17H16N2O6SNa2
  • MW:422.363 Da
  • Appearance:White to off-white powder
  • Purity:≥92.0%

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Product Name Qty
Carbenicillin Disodium Salt
5 g
$99.99
Carbenicillin Disodium Salt
25 g
$174.99
Carbenicillin Disodium Salt
100 g
$499.99
Carbenicillin Disodium Salt
1 g
$39.99

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Description

Carbenicillin Disodium Salt is a penicillin-derived β-lactam antibiotic that interferes with cell wall synthesis, primarily in gram-negative bacteria such as Pseudomonas aeruginosa, while showing low toxicity to plant tissues. Carbenicillin acylates the penicillin-sensitive transpeptidase C-terminal area by opening the lactam ring. This inactivation intercepts the cross-linkage of peptidoglycan strands, by impeding the third and last phase of bacterial cell wall synthesis. This prompts inadequate bacterial cell wall synthesis and causes cell lysis.

Applications

• Used in selection protocols over ampicillin due to its increased stability
• Used in genetic transformation applications to select for AmpR transformed cells
• Used to regulate bacterial growth in plants, yielding low regeneration frequencies
• Used as a gene selection antibiotic in plant biology utilizing the CRISPR/CAS9 system

 

More Information
Alternate Name/Synonyms
Carbecin; Microcillin; Pyocianil; Hyoper; Geopen; Pyopen; Fugacillin; Gripenin; Pyoclox; Piopen
SKU
C-1385
CAS #
4800-94-6
Chemical Name
disodium;(2S,5R,6R)-6-[(2-carboxylato-2-phenylacetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
Chemical Formula
C17H16N2O6SNa2
Molecular Weight
422.363 Da
Appearance
White to off-white powder
Purity
≥92.0%
Solubility
Soluble in water: clear and slightly yellow solution at 50 mg/mL
Melting Point
N/A
Preparation
N/A
Storage Temp
+4°C, packaged under inert gas.
THERAPEUTIC AREA
Antibacterial
USE
Carbenicillin disodium salt is a penicillin-derived, β-lactam antibiotic which inhibits the synthesis of peptidoglycan, a key component of the bacterial cell wall. In studies investigating the roles of biogenic polyamines, spermidine and spermine, on antibiotic susceptibility of several microorganisms it was observed that the mean inhibitory concentration (MIC) of β-lactam antibiotics such as Carbenicillin was decreased with the addition of spermidine and spermine to cultures of Escherichia coli and Salmonella enterica.
Merck Index
N/A
MDL NUMBER
MFCD00077683
CHEMACX
X1026446-7
INCHI
InChI=1S/C17H18N2O6S.2Na/c1-17(2)11(16(24)25)19-13(21)10(14(19)26-17)18-12(20)9(15(22)23)8-6-4-3-5-7-8;;/h3-7,9-11,14H,1-2H3,(H,18,20)(H,22,23)(H,24,25);;/q;2*+1/p-2/t9?,10-,11+,14-;;/m1../s1
SMILES
CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)C(c3ccccc3)C(=O)[O-])C(=O)[O-])C.[Na+].[Na+]
Peptide sequence
Not Applicable
RTECS
ON9105000
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Avoid contact with skin, eyes or clothing. Wash contaminated clothing before reuse. Do not eat, drink or smoke when using this product. Use personal protective equipment as required. Do not breathe dust/fume/gas/mist/vapors/spray. Use with local exhaust ventilation. Corrosive hazard. Wear protective gloves/clothing and eye/face protection
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
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GHS PICTOGRAMS
Handling Avoid contact with skin, eyes or clothing. Wash contaminated clothing before reuse. Do not eat, drink or smoke when using this product. Use personal protective equipment as required. Do not breathe dust/fume/gas/mist/vapors/spray. Use with local exhaust ventilation. Corrosive hazard. Wear protective gloves/clothing and eye/face protection
UN #'S Not Applicable
Packing Group Not Applicable
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