Cycloheximide

SKU
C-1189
  • CAS:66-81-9
  • Formula:C15H23NO4
  • MW:281.35 Da
  • Appearance:White or cream color powder
  • Purity:≥95.0%

2

1

0

Product Name Qty
Cycloheximide
50 g
$625.46
Cycloheximide
1 g
$44.13
Cycloheximide
25 g
$362.93
Cycloheximide
5 g
$95.70
Cycloheximide
10 g
$155.23

USE PROMO CODE: SUMMER25 AT CHECKOUT FOR 25% OFF

*IF >1GM HAZARDOUS BOX FEE APPLIED*

Description

Cycloheximide is an antibiotic produced by Streptomyces sp. that activates against yeasts and fungi. It inhibits protein synthesis thru DNA translation arrest in eukaryotes. Cycloheximide also inhibits chain initiation and chain elongation by acting on 60S subunits of eukaryote ribosome.

Applications

• Used as an inhibitor to study cell-free protein biosynthesis in eukaryotes
• Used to block ribosome-dependent in vivo polypeptide synthesis
• Used in genome editing utilizing the CRISPR/Cas9 system
• Used to clear macrophages in atherosclerotic plaques
• Used to activate cumulus-free equine oocytes, and to have neuroprotective properties

Cycloheximide is in stock. Call for bulk quotations, typical lead for subdivision, packing and shipping larger quantities is 7-14 days. Research size order 100mg 250mg lead is shorter.

 

GHS PICTOGRAMS
Handling Avoid contact with skin, eyes or clothing. Wash contaminated clothing before reuse. Do not eat, drink or smoke when using this product. Use personal protective equipment as required. Do not breathe dust/fume/gas/mist/vapors/spray. Use with local exhaust ventilation. Corrosive hazard. Wear protective gloves/clothing and eye/face protection.
UN #'S UN 2811
Packing Group I
Citations Impairment of D-alanine biosynthesis in Mycobacterium smegmatis determines decreased intracellular survival in human macrophages
GRASP55 Senses Glucose Deprivation through O-GlcNAcylation to Promote Autophagosome-Lysosome Fusion
Dual action antifungal small molecule modulates multidrug efflux and TOR signaling
Sphingomyelin organization is required for vesicle biogenesis at the Golgi complex
SUMOylation regulates the SNF1 protein kinase
Sphingomyelin homeostasis is required to form functional enzymatic domains at the trans-Golgi network
p53 controls prostate-derived factor/macrophage inhibitory cytokine/NSAID-activated gene expression in response to cell density, DNA damage and hypoxia through diverse mechanisms
Insulin-like growth factor binding protein-3 leads to insulin resistance in adipocytes
IL-27 activates human monocytes via STAT1 and suppresses IL-10 production but the inflammatory functions of IL-27 are abrogated by TLRs and p38
Inter-isoform-dependent Regulation of the Drosophila Master Transcriptional Regulator SIN3
Rapid turnover of the mTOR complex 1 (mTORC1) repressor REDD1 and activation of mTORC1 signaling following inhibition of protein synthesis
Prostate derived factor in human prostate cancer cells: gene induction by vitamin D via a p53-dependent mechanism and inhibition of prostate cancer cell growth
Copper modulates the large dense core vesicle secretory pathway in PC12 cells
Ligand-independent and agonist-mediated degradation of estrogen receptor-alpha in breast carcinoma cells: evidence for distinct degradative pathways
The Translational Repressor 4E-BP1 Contributes to Diabetes-Induced Visual Dysfunction
Universal quantification of structurally diverse natural products using an evaporative light scattering detector
Solubility-promoting function of Hsp90 contributes to client maturation and robust cell growth
Ubiquitin-specific protease 25 functions in Endoplasmic Reticulum-associated degradation
Functional significance of vitamin D receptor FokI polymorphism in human breast cancer cells
CTC medium: A novel dodine-free selective medium for isolating entomopathogenic fungi, especially Metarhizium acridum, from soil
Fgf-dependent otic induction requires competence provided by Foxi1 and Dlx3b
Plasmid transformation and expression of the firefly luciferase in Microbacterium testaceum type and endophytic colonizing field strains
Regulation of protein and mRNA expression of the mTORC1 repressor REDD1 in response to leucine and serum
Interaction of the polyglutamine protein ataxin-3 with Rad23 regulates toxicity in Drosophila models of Spinocerebellar Ataxia Type 3
The eIF2 alpha Kinases GCN2 and PERK Regulate Phosphorylation of TOR Target Proteins and Differential Translation of mRNAs
Utilizing a Microbial Natural Product to Investigate Cellular Circuitry Governing Fungal Drug Resistance and Morphogenesis
Type I Interferon Mediates Th2 Reprogramming and Acute Suppression of Effector Functions
Role of glycogen synthase kinase 3β in rapamycin-mediated cell cycle regulation and chemosensitivity
Mycological Characteristics of Ophiostoma quercus, a Sap-staining Fungus Isolated from Japanese Black Pine in Korea
Detection and phylogenetic analysis of Coccidioides posadasii in Arizona soil samples
The potential roles of c-Jun N-terminal kinase (JNK) during the maturation and aging of oocytes produced by a marine protostome worm
AXL degradation in combination with EGFR-TKI can delay and overcome acquired resistance in human non-small cell lung cancer cells
Differential toxicity of ataxin-3 isoforms in Drosophila models of Spinocerebellar Ataxia Type 3
We found other products you might like!
To Top