CHIR99021, potent and highly selective inhibitor of GSK3
- Appearance:Tan solid
- Purity:99% by TLC NMR (Conforms)
CHIR-99021 (252917-06-9) is a potent and selective inhibitor of glycogen synthase kinase-3β (GSK3β, IC50 = 5 nM) and GSK3α (IC50 = 10 nM). Induces osteoblastogenesis, increases mineralization and inhibits adipogenesis in ST2 cells. Promotes replication and survival of pancreatic beta cells3. CHIR-99021 enhances differentiation and reduces proliferation of adult human olfactory epithelium neural precursors. Cell permeable and active in vivo.
|Handling||Do not take internally. Wear gloves and mask when handling the product.Avoid contact by all modes of exposure.|
|UN #'S||Not Applicable|
|Packing Group||Not Applicable|