CHIR99021, potent and highly selective inhibitor of GSK3

SKU
C-1702
  • CAS:252917-06-9
  • Formula:C22H18CI2N8
  • MW:465.35
  • Appearance:Tan solid
  • Purity:99% by TLC NMR (Conforms)
Product Name Qty
CHIR-99021
5 mg
$75.00
CHIR-99021
25 mg
$325.00

CHIR-99021 (252917-06-9) is a potent and selective inhibitor of glycogen synthase kinase-3β (GSK3β, IC50 = 5 nM) and GSK3α (IC50 = 10 nM). Induces osteoblastogenesis, increases mineralization and inhibits adipogenesis in ST2 cells. Promotes replication and survival of pancreatic beta cells3. CHIR-99021 enhances differentiation and reduces proliferation of adult human olfactory epithelium neural precursors. Cell permeable and active in vivo.

More Information
Alternate Name/Synonyms
6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile; CT99021, CHIR99021
SKU
C-1702
CAS #
252917-06-9
Chemical Name
6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile
Chemical Formula
C22H18CI2N8
Molecular Weight
465.35
Appearance
Tan solid
Purity
99% by TLC NMR (Conforms)
Solubility
Soluble in DMSO (up to 25 mg/ml).
Storage Temp
-20°C. Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
THERAPEUTIC AREA
It is used in stem cell differentiation and reprogramming
USE
GSK3β inhibitor.
MDL NUMBER
MFCD11846251
CHEMACX
X1755647-3
INCHI
InChI=1S/C22H18Cl2N8/c1-13-10-29-21(31-13)17-12-30-22(32-20(17)16-4-3-15(23)8-18(16)24)27-7-6-26-19-5-2-14(9-25)11-28-19/h2-5,8,10-12H,6-7H2,1H3,(H,26,28)(H,29,31)(H,27,30,32)
SMILES
CC1=CNC(=N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Do not take internally. Wear gloves and mask when handling the product.Avoid contact by all modes of exposure.
Certificate of Analysis 1
Certificate of Analysis 2
GHS PICTOGRAMS
Handling Do not take internally. Wear gloves and mask when handling the product.Avoid contact by all modes of exposure.
UN #'S Not Applicable
Packing Group Not Applicable
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