Chloramphenicol palmitate

SKU
C-2625
  • CAS:530-43-8
  • Formula:C27H42Cl2N2O6
  • MW:561.5 Da
  • Appearance:White solid
  • Purity:>99% by HPLC

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Starting at $148.07

Product Name Qty
Chloramphenicol palmitate
5 mg
$148.07
Chloramphenicol palmitate
25 mg
$517.14

Description

Chloramphenicol palmitate is prepared by acylation of chloramphenicol with palmitic acid. Although chloramphenicol palmitate is a more hydrophobic drug which should enhance bioavailability, the primary advantage of the ester is to mask the taste of chloramphenicol in oral formulations.

Chloramphenicol palmitate is significantly less active than chloramphenicol but acts as a prodrug, being readily hydrolysed by acid and esterase in the gut to release chloramphenicol.

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
Chloramphenicol 3-palmitate; Detreopal; CAP-palmitate; Chloromycetin palmitate
SKU
C-2625
CAS #
530-43-8
Chemical Name
[(2R,3R)-2-[(2,2-dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl] hexadecanoate
Chemical Formula
C27H42Cl2N2O6
Molecular Weight
561.5 Da
Appearance
White solid
Purity
>99% by HPLC
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
Stability
N/A
Storage Temp
-20°C
USE
A prodrug that readily hydrolysed by acid and esterase in the gut to release chloramphenicol.
MDL NUMBER
MFCD00083597
INCHI
InChI=1S/C27H42Cl2N2O6/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-24(32)37-20-23(30-27(34)26(28)29)25(33)21-16-18-22(19-17-21)31(35)36/h16-19,23,25-26,33H,2-15,20H2,1H3,(H,30,34)/t23-,25-/m1/s1
SMILES
CCCCCCCCCCCCCCCC(=O)OC[C@H]([C@@H](c1ccc(cc1)[N+](=O)[O-])O)NC(=O)C(Cl)Cl
Handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire protection.
Promo text for AGS discount
N/A
GHS PICTOGRAMS
Handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire protection.
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