Chlorothricin

SKU
C-1400
  • CAS:34707-92-1
  • Formula:C50H63CIO16
  • MW:955.5
  • Appearance:White Powder
  • Purity:99% by HPLC
Product Name Qty
Chlorothricin
1 mg
$174.21
Chlorothricin
5 mg
$530.45

The tetronic acid, chlorothricin is an unusual macrocyclic antibiotic from Streptomyces sp. Related to kijanimicin, sccharocarcins, tetrocarcin and versipelostatin. It shows inhibitory activity against cholesterol biosynthesis from mevalonate and inhibits pyruvate carboxylases purified from rat liver, chicken liver and Azobacter vinelandii.

More Information
Alternate Name/Synonyms
Antibiotic 818A
SKU
C-1400
CAS #
34707-92-1
Chemical Name
(1S,3R,6R,7E,13R,16S,17S,21R,22R)-17-((4-O-[3-O-(3-CHLORO-6-METHOXY-2-METHYLBENZOYL)-2,6-DIDEOXY-Β-D-ARABINO-HEXOPYRANOSYL]-2,6-DIDEOXY-Β-D-ARABINO-HEXOPYRANOSYL)OXY)-28-HYDROXY-3,22-DIMETHYL-23 ,26-DIOXO-24,27-DIOXAPENTACYCLO[23.2.1.01,6.013,22.016,21]OC
Chemical Formula
C50H63CIO16
Molecular Weight
955.5
Appearance
White Powder
Purity
99% by HPLC
Solubility
Readily Soluble in Water
Stability
N/A
Storage Temp
-20°C
THERAPEUTIC AREA
Not Available
USE
A spirotetronic acid antibiotic inhibitor of pyruvate carboxylase
MDL NUMBER
MFCD08062298
CHEMACX
X6952241-8
INCHI
InChI=1S/C50H63ClO16/c1-24-23-50-29(20-31(24)45(55)56)13-10-8-7-9-12-28-16-17-30-32(49(28,5)48(59)66-43(44(50)54)47(58)67-50)14-11-15-35(30)63-38-21-34(52)42(27(4)62-38)65-39-22-37(41(53)26(3)61-39)64-46(57)40-25(2)33(51)18-19-36(40)60-6/h10,13,16-20,24,26-30,32,34-35,37-39,41-42,52-54H,7-9,11-12,14-15,21-23H2,1-6H3,(H,55,56)/b13-10+/t24-,26-,27-,28-,29-,30+,32-,34-,35+,37-,38+,39+,41-,42-,49-,50+/m1/s1
SMILES
Cc1c(ccc(c1C(=O)O[C@@H]2C[C@@H](O[C@@H]([C@H]2O)C)O[C@@H]3[C@H](O[C@H](C[C@H]3O)O[C@H]4CCC[C@@H]5[C@@H]4C=C[C@@H]6[C@]5(C(=O)OC7=C([C@@]8(C[C@H](C(=C[C@H]8/C=C/CCCC6)C(=O)O)C)OC7=O)O)C)C)OC)Cl
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Protect from Light
Citations
BIOENERGETICS: Cross-talk between Mitochondrial Malate Dehydrogenase and the Cytochrome bc1 Complex Qiyu Wang, Linda Yu, and Chang-An Yu J. Biol. Chem., Apr 2010; 285: 10408 - 10414.
Citations_Hyperlink
http://www.jbc.org/cgi/reprint/285/14/10408
Certificate of Analysis 1
Promo text for AGS discount
N/A
GHS PICTOGRAMS
Handling Protect from Light
UN #'S Not Applicable
Packing Group Not Applicable
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