- Formula:C27 H28 O9
- Appearance:White Powder
Chrysomycin B is a minor analogue in a complex of C-glycoside anti-tumor actives isolated fromStreptomyces. Chrysomycin B, containing a methyl group in the 8-position, is less active than its vinyl analogue (Chrysomycin A), albeit still a potent anti-tumor active and an inhibitor of the catalytic activity of human topoisomerase II. More recent research on related metabolites, the gilvocarcins, suggests that chrysomycins may act as photoactivated crosslinkers of DNA to histones. Topoisomerase II Inhibitors. Inhibitors of the catalytic activity of human topoisomerase II. Exhibits anti-tumor activity against human cell lines K562, HT29, MCF7, PC6, MKN28.
C27 H28 O9
Soluble in DMF or DMSO. Moderately soluble in methanol or ethanol.
Chrysomycin B is a minor analogue in a complex of C-glycoside anti-tumor actives isolated fromStreptomyces
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