Chrysomycin B

SKU
C-1700
  • CAS:83852-56-6
  • Formula:C27 H28 O9
  • MW:496.509
  • Appearance:White Powder
Product Name Qty
Chrysomycin B
0.5 mg
$248.35
Chrysomycin B
2.5 mg
$877.48
Chrysomycin B is a minor analogue in a complex of C-glycoside anti-tumor actives isolated fromStreptomyces. Chrysomycin B, containing a methyl group in the 8-position, is less active than its vinyl analogue (Chrysomycin A), albeit still a potent anti-tumor active and an inhibitor of the catalytic activity of human topoisomerase II. More recent research on related metabolites, the gilvocarcins, suggests that chrysomycins may act as photoactivated crosslinkers of DNA to histones. Topoisomerase II Inhibitors. Inhibitors of the catalytic activity of human topoisomerase II. Exhibits anti-tumor activity against human cell lines K562, HT29, MCF7, PC6, MKN28.
More Information
SKU
C-1700
CAS #
83852-56-6
Chemical Formula
C27 H28 O9
Molecular Weight
496.509
Appearance
White Powder
Solubility
Soluble in DMF or DMSO. Moderately soluble in methanol or ethanol.
Storage Temp
+4°C
THERAPEUTIC AREA
Oncological Disorders
USE
Chrysomycin B is a minor analogue in a complex of C-glycoside anti-tumor actives isolated fromStreptomyces
MDL NUMBER
MFCD07370132
CHEMACX
X1495719-0
INCHI
InChI=1S/C27H28O9/c1-11-8-15-19(17(9-11)33-4)14-10-18(34-5)21-16(28)7-6-13(20(21)22(14)36-26(15)31)23-25(30)27(3,32)24(29)12(2)35-23/h6-10,12,23-25,28-30,32H,1-5H3
SMILES
Cc1cc2c(c3cc(c4c(ccc(c4c3oc2=O)C5C(C(C(C(O5)C)O)(C)O)O)O)OC)c(c1)OC
Handling
Shelf, Protect from light
HandlingShelf, Protect from light
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