Chymostatin

SKU
C-1469
  • CAS:9076-44-2
  • Formula:C31H41N7O6
  • MW:604.24 Da
  • Appearance:White to off-white powder

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Product Name Qty
Chymostatin, microbial
5 mg
$99.96

This Chymostatin consists of A,B,C forms, where A is a major form. Acts as a protease inhibitor, specificallyfor CTR (chymotrypsin) (ID= 150g/ml), Papain (ID= 7.5g/ml), Cathepsin G, as well as most cysteine proteases. Inquire for additional product specification. A (Leu), B (Ile), C (Val) are reported (via X value). Chymostatin inhibits chymase and reduces myocardial active TGF-β1 levels.

 

 

 

 

 

More Information
Alternate Name/Synonyms
N-(Nα-Carbonyl-Cpd-X-Phe-al)-Phe (Cpd = capreomycidine) (capreomycidine = [S,S]-α-(2-Iminohexahydro-4-pyrimidyl)glycine)
SKU
C-1469
CAS #
9076-44-2
Chemical Name
(2S)-2-[[(1S)-1-(2-amino-1,4,5,6-tetrahydropyrimidin-6-yl)-2-[[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxo-3-phenylpropan-2-yl]amino]pentan-2-yl]amino]-2-oxoethyl]carbamoylamino]-3-phenylpropanoic acid
Chemical Formula
C31H41N7O6
Molecular Weight
604.24 Da
Appearance
White to off-white powder
Purity
N/A
Solubility
Up to 20 mg/mL in DMSO, up to 10 mg/mL in 5% Glacial Acetic Acid
Melting Point
N/A
Preparation
N/A
Storage Temp
-20°C, desiccated
THERAPEUTIC AREA
Not Available
USE
Chymostatin is a bioactive peptide protease inhibitor that contains chymostatin A as a major form. The compound specifically inhibits chymotrypsin (CTR) (ID50 = 150 ηg/ml), papain (ID50 = 7.5 μg/ml), and cathepsin G along with most cysteine proteases such as cathepsin A, B, H, and L. The compound has been noted as a strong inhibitor of cathepsins A, B, and C. Chymostatin at an effective concentration of 10 to 100 μM weakly inhibits human leukocyte Elastase-1. In rat muscle homogenates chymostatin inhibited the protease cathepsin B and other soluble Ca2+ activated proteases. In the same study, chymostatin decreased protein break down by 20-40% without inhibiting protein production.
Merck Index
N/A
MDL NUMBER
MFCD00071059
CHEMACX
X1088602-1
INCHI
InChI=1S/C31H41N7O6/c1-19(2)15-24(27(40)34-22(18-39)16-20-9-5-3-6-10-20)35-28(41)26(23-13-14-33-30(32)36-23)38-31(44)37-25(29(42)43)17-21-11-7-4-8-12-21/h3-12,18-19,22-26H,13-17H2,1-2H3,(H,34,40)(H,35,41)(H,42,43)(H3,32,33,36)(H2,37,38,44)/t22-,23?,24-,25-,26-/m0/s1
SMILES
CC(C)C[C@@H](C(=O)N[C@@H](Cc1ccccc1)C=O)NC(=O)[C@H](C2CCNC(=N)N2)NC(=O)N[C@@H](Cc3ccccc3)C(=O)O
RTECS
GC3047700
Handling
Corrosive hazard. Wear protective gloves/clothing and eye/face protection. Handle in accordance with good industrial hygiene and safety practice.
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
Handling Corrosive hazard. Wear protective gloves/clothing and eye/face protection. Handle in accordance with good industrial hygiene and safety practice.
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