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Citalopram HBr

SKU
C-2573
  • CAS:59729-32-7
  • Formula:C20H21FN2O•HBr
  • MW:405.3 Da
  • Appearance:White powder
  • Purity:>98% (TLC); NMR (Conforms)
Product Name Qty
Citalopram HBr
20 mg
$83.47
Citalopram HBr
100 mg
$130.42
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Description

Citalopram hydrobromide is a selective serotonin reuptake inhibitor (SSRI) that targets the serotonin transporter within synaptic clefts. As a result, citalopram is capable of inhibiting serotonin uptake without exerting a significant inhibitory effect on dopamine or norepinephrine.

Applications

Citalopram is often prescribed in clinical medicine as an antidepressant. In addition, citalopram is known to have a wide range of off-label uses, including the treatment of generalized anxiety disorder and obsessive-compulsive disorder. It has also been shown to offer cardioprotective benefits by inhibiting platelet aggregation induced by collagen. Recent research has demonstrated that citalopram can induce epigenetic changes in the human genome by altering methylation of several hundred individual genes.

Displays cardioprotective effects in part by reducing expression of cytokine-induced endothelial adhesion molecules, ICAM-1 and VCAM-1. Attenuates ethanol intake.

 

More Information
Alternate Name/Synonyms
citalopram hydrobromide; Cipramil; Celexa; hydrobromide; Elopram; Seropram; Bonitrile HBr; Nitalapram HBr; Prepram HBr
SKU
C-2573
CAS #
59729-32-7
Chemical Name
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-3H-2-benzofuran-5-carbonitrile;hydrobromide
Chemical Formula
C20H21FN2O•HBr
Molecular Weight
405.3 Da
Appearance
White powder
Purity
>98% (TLC); NMR (Conforms)
Solubility
May be dissolved in DMSO (25 mg/mL); or ethanol (20 mg/mL); or water (4 mg/mL)
Storage Temp
Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at -20°C for up to 2 months.
THERAPEUTIC AREA
Psychological disorders
USE
Potent and selective serotonin uptake inhibitor as antidepressant. Citalopram is used to treat depression. It may improve your energy level and feelings of well-being. Citalopram is known as a selective serotonin reuptake inhibitor (SSRI). This medication works by helping to restore the balance of a certain natural substance (serotonin) in the brain.
MDL NUMBER
MFCD02101306
CHEMACX
X1210998-3
INCHI
InChI=1S/C20H21FN2O.BrH/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20;/h4-9,12H,3,10-11,14H2,1-2H3;1H
SMILES
CN(C)CCCC1(c2ccc(cc2CO1)C#N)c3ccc(cc3)F.Br
RTECS
NP6313500
UN #'S
UN 3249
PACKING GROUP
III
HAZARD CLASS
Class 6.1
Handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. Keep container tightly closed in a dry and well-ventilated place.
GHS PICTOGRAMS
HandlingAvoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. Keep container tightly closed in a dry and well-ventilated place.
UN #'SUN 3249
Packing GroupIII
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