CJ-21058 isolated from Phoma sp. is a close analog of equisetin, a fungal toxin.

Equisetin differs only in having a hydrogen atom at C-4 position of CJ-21058. It is also known to show a broad range of biological activites such as antibacterial, anti-HIV, cytotoxicity and DNA binding properties. The striking structural similarities between CJ-21058 and qeuisetin as well as their potent antibacterial properties point towards a possible correlation between antibacterial and SecA inhibitory activities of these compounds.

CJ-21058 shows antibacterial activity against gram-positive multi-drug resistant bacteria such as Staphylococcus aureus and Enterococcus faecalis(MIC=5µg/ml) by inhibiting ATP-dependent translocation of precursor proteins across a bacterial cell membrane. But it has no activity against Streptococcus pyogenes and Escherichia coli. 

Product References

• CJ-21,058, a new SecA inhibitor isolated from a fungus, Suqie Y., et al. J Antibiot, 55(1):25-9 (2002)

• SecA inhibitors: next generation antimicrobials, Weixuan Chen, et al., J. Chinese Pharmaceutical Sciences (2012)