CJ-21058

SKU
C-2398
  • CAS:405072-57-3
  • Formula:C23H33NO4
  • MW:387.5
  • Appearance:Off-white solid
  • Purity:≥98% (HPLC)
Product Name Qty
CJ-21058
1 mg
$102.52
CJ-21058
5 mg
$410.07

CJ-21058 isolated from Phoma sp. is a close analog of equisetin, a fungal toxin.

Equisetin differs only in having a hydrogen atom at C-4 position of CJ-21058. It is also known to show a broad range of biological activites such as antibacterial, anti-HIV, cytotoxicity and DNA binding properties. The striking structural similarities between CJ-21058 and qeuisetin as well as their potent antibacterial properties point towards a possible correlation between antibacterial and SecA inhibitory activities of these compounds.

CJ-21058 shows antibacterial activity against gram-positive multi-drug resistant bacteria such as Staphylococcus aureus and Enterococcus faecalis(MIC=5µg/ml) by inhibiting ATP-dependent translocation of precursor proteins across a bacterial cell membrane. But it has no activity against Streptococcus pyogenes and Escherichia coli

 

Product References

More Information
SKU
C-2398
CAS #
405072-57-3
Chemical Name
(5R,Z)-3-(Hydroxy((1R,2S,6S,8aS)-1,3,6-trimethyl-2-((E)-prop-1-en-1-yl)-1,2,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl)methylene)-5-(hydroxymethyl)-1-methylpyrrolidine-2,4-dione
Chemical Formula
C23H33NO4
Molecular Weight
387.5
Appearance
Off-white solid
Purity
≥98% (HPLC)
Solubility
Soluble in methylene chloride, DMSO or methanol
Storage Temp
-20°C
GHS PICTOGRAMS
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