CK-666

SKU
C-2917
  • CAS:442633-00-3
  • Formula:C18H17FN2O
  • MW:296.3
  • Appearance:Cream-colored powder

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Product Name Qty
CK-666
5 mg
$91.80
CK-666
25 mg
$209.10

Description

CK-666 is a potent, selective and reversible inhibitor of actin assembly mediated by actin related protein Arp2/3 complex. It binds to Arp2/3 complex, stabilizes the inactive state of the complex and prevents movement into active conformation. CK-666 attenuates blood-brain barrier (BBB) dysfunction induced by methamphetamine. It is an important new tool for studying actin assembly and the diverse range of actin-related processes in both normal physiology and pathophysiology.

 

Application

• CK-666 may be used to study Arp2/3-mediated structual changes in cells.

• IC50 = 4 µM for human ARP2/3

 

More Information
Alternate Name/Synonyms
2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]-benzamide, CK-0944666, Actin Assembly Inhibitor XIII, CK 666
SKU
C-2917
CAS #
442633-00-3
Chemical Name
2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide
Chemical Formula
C18H17FN2O
Molecular Weight
296.3
Appearance
Cream-colored powder
Solubility
May be dissolved in DMSO (45 mg/ml); or ethanol (30 mg/ml)
Storage Temp
Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 3 months.
MDL NUMBER
MFCD03036271
PubChecm ID
589075
INCHI
InChI=1S/C18H17FN2O/c1-12-13(14-6-3-5-9-17(14)21-12)10-11-20-18(22)15-7-2-4-8-16(15)19/h2-9,21H,10-11H2,1H3,(H,20,22)
SMILES
CC1=C(C2=CC=CC=C2N1)CCNC(=O)C3=CC=CC=C3F
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