clasto-Lactacystin-b-lactone, Synthetic

SKU
L-1055
  • CAS:155975-72-7
  • Formula:C10H15NO4
  • MW:213.2
  • Appearance:White Solid
  • Purity:>95%
Product Name Qty
clasto-Lactacystin β-lactone, Synthetic
200 ug
$329.44
clasto-Lactacystin β-lactone, Synthetic
100 ug
$228.92

Synthetic. Highly specific, cell permeable, and irreversible 20S proteasome inhibitor. It is believed lactacystin acts as a precursor for clasto-lactacystin b-lactone. Parkin Directly Modulates 26S Proteasome Activity.ASK1 Negatively Regulates the 26 S Proteasome.Parkin Ubiquitinates and Promotes the Degradation of RanBP2.Acquired resistance to TRAIL-induced apoptosis in human ovarian cancer cells is conferred by increased turnover of mature caspase-3.

 

More Information
Alternate Name/Synonyms
Omualide
SKU
L-1055
CAS #
155975-72-7
Chemical Name
1R-[1S-1HYDROXY-2-METHYLPROPYL]-4R-METHYL-6-OXA-2-AZABICYCLO[3.2.0]HEPTANE-3,7-DIONE
Chemical Formula
C10H15NO4
Molecular Weight
213.2
Appearance
White Solid
Purity
>95%
Solubility
Soluble in Chloroform or DMSO. Moderately Soluble in Water.
Melting Point
161.31 °C
Storage Temp
Store at -20°C. Stock solutions are stable for up to 1 month at -80°C.
THERAPEUTIC AREA
Not Available
USE
Effect of proteasome inhibitor clasto-lactacystin-beta-lactone on the proteome of the haloarchaeon Haloferax volcanii
MDL NUMBER
MFCD01076526
CHEMACX
X1094109-2
INCHI
InChI=1S/C10H15NO4/c1-4(2)7-10(9(14)15-7)6(12)5(3)8(13)11-10/h4-7,12H,1-3H3,(H,11,13)/t5-,6+,7+,10+/m1/s1
SMILES
O=C1O[C@@H](C(C)C)[C@]12NC(=O)[C@@H]([C@@H]2O)C
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
UN 2811
PACKING GROUP
III
HAZARD CLASS
Not Applicable
Handling
Store in Tightly Sealed Vial, protect from Light Stock solutionsstable at -80°C 1 month.
Citations
NEUROBIOLOGY OF DISEASE: Parkin Directly Modulates 26S Proteasome Activity Ji Won Um, Eunju Im, Hyun Jung Lee, Boram Min, Lang Yoo, Jiho Yoo, Hermann Lübbert, Christine Stichel-Gunkel, Hyun-Soo Cho, Jong Bok Yoon, and Kwang Chul Chung J. Neurosci., Sep 2010; 30: 11805 - 11814.
Citations_Hyperlink
http://www.jneurosci.org/cgi/reprint/30/35/11805
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
Handling Store in Tightly Sealed Vial, protect from Light Stock solutionsstable at -80°C 1 month.
UN #'S UN 2811
Packing Group III
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