Colchicine

SKU
C-1164
  • CAS:64-86-8
  • Formula:C22H25NO6
  • MW:399.4 Da
  • Appearance:Crystalline Powder
  • Purity:≥99%

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Starting at $109.00

Product Name Qty
Colchicine
1 g
$109.00

Description

Colchicine is a toxic alkaloid isolated from Colchicum autumnale and other Colchica species. It has antimitotic and anticancer properties. The alkaloid displays a high affinity for binding to the ends of microtubules, interfering with addition of further dimers binding to them.

It has been reported that Colchicine induces apoptosis by causing alterations in Ca2+ responses to chemical depolarization and a moderate, but progressive, increase in the resting intracellular Ca2+ concentration in rat cerebellar granule cells (CGC) model.

It is known as a treatment for gout.

 

Application

• Study for cell division

• Anti-inflammatory agent

• Chemotherapeutic agent

• Therapeutic agent

 

Reference

• “Addition of colchicine-tubulin complex to microtubule ends: The mechanism of substoichiometric colchicine poisoning”

• “Interactions of colchicine with tubulin”

• “Colchicine Induces Apoptosis in Cerebellar Granule Cells”

 

Not for human therapeutic use or for medicinal purposes. For research applications only.

More Information
Alternate Name/Synonyms
N-​[(7S)-​1,​2,​3,​10-​ tetramethoxy-​9-​oxo-​5,​6,​7,​9-​tetrahydrobenzo​[a]​heptalen-​ 7-​yl]​acetamide; 64-86-8; Colchicin; Colchicina; Colchisol; Condylon; Colcin
SKU
C-1164
CAS #
64-86-8
Chemical Name
N-[(7S)-1,2,3,10- tetramethoxy-9-oxo-5,6,7,9- tetrahydrobenzo[a]heptalen- 7-yl]acetamide
Chemical Formula
C22H25NO6
Molecular Weight
399.4 Da
Appearance
Crystalline Powder
Purity
≥99%
Solubility
Soluble in DMSO and water (10 mg/mL)
Melting Point
150-160°C (decomp.)
Storage Temp
-20°C
THERAPEUTIC AREA
Inflammatory Diseases
USE
Colchicine is used to treat gout. Antimitotic and anticancer properties. Mitosis inhibitor.
MDL NUMBER
MFCD00078484
CHEMACX
X1001272-1
INCHI
InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1
SMILES
CC(=O)N[C@H]1CCc2cc(c(c(c2-c3c1cc(=O)c(cc3)OC)OC)OC)OC
RTECS
GH0700000
UN #'S
UN 1544
PACKING GROUP
I
Handling
Protect from light and air.
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
GHS PICTOGRAMS
Handling Protect from light and air.
UN #'S UN 1544
Packing Group I
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