Colchicine

SKU

C-1164

CAS:64-86-8
Formula:C₂₂H₂₅NO₆
MW:399.4 Da
Appearance:Crystalline Powder
Purity:≥99%

SDS

CofA

Product Name	Qty
Colchicine 1 g $109.00

Details

Description

Colchicine is a toxic alkaloid isolated from Colchicum autumnale and other Colchica species. It has antimitotic and anticancer properties. The alkaloid displays a high affinity for binding to the ends of microtubules, interfering with addition of further dimers binding to them.

It has been reported that Colchicine induces apoptosis by causing alterations in Ca2+ responses to chemical depolarization and a moderate, but progressive, increase in the resting intracellular Ca2+ concentration in rat cerebellar granule cells (CGC) model.

It is known as a treatment for gout.

Application

• Study for cell division

• Anti-inflammatory agent

• Chemotherapeutic agent

• Therapeutic agent

Reference

• “Addition of colchicine-tubulin complex to microtubule ends: The mechanism of substoichiometric colchicine poisoning”

• “Interactions of colchicine with tubulin”

• “Colchicine Induces Apoptosis in Cerebellar Granule Cells”

Not for human therapeutic use or for medicinal purposes. For research applications only.

Specifications

More Information

Alternate Name/Synonyms

N-[(7S)-1,2,3,10- tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen- 7-yl]acetamide; 64-86-8; Colchicin; Colchicina; Colchisol; Condylon; Colcin

SKU

C-1164

CAS #

64-86-8

Chemical Name

N-[(7S)-1,2,3,10- tetramethoxy-9-oxo-5,6,7,9- tetrahydrobenzo[a]heptalen- 7-yl]acetamide

Chemical Formula

C₂₂H₂₅NO₆

Molecular Weight

399.4 Da

Appearance

Crystalline Powder

Purity

≥99%

Solubility

Soluble in DMSO and water (10 mg/mL)

Melting Point

150-160°C (decomp.)

Storage Temp

-20°C

THERAPEUTIC AREA

Inflammatory Diseases

USE

Colchicine is used to treat gout. Antimitotic and anticancer properties. Mitosis inhibitor.

MDL NUMBER

MFCD00078484

CHEMACX

X1001272-1

INCHI

InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1

SMILES

CC(=O)N[C@H]1CCc2cc(c(c(c2-c3c1cc(=O)c(cc3)OC)OC)OC)OC

RTECS

GH0700000

UN #'S

UN 1544

PACKING GROUP

Handling

Protect from light and air.

Certificate of Analysis 1

C-1164, L1010.pdf

Certificate of Analysis 2