Description

Colchicine is a toxic alkaloid isolated from Colchicum autumnale and other Colchica species. It has antimitotic and anticancer properties. The alkaloid displays a high affinity for binding to the ends of microtubules, interfering with addition of further dimers binding to them.

It has been reported that Colchicine induces apoptosis by causing alterations in Ca2+ responses to chemical depolarization and a moderate, but progressive, increase in the resting intracellular Ca2+ concentration in rat cerebellar granule cells (CGC) model.

It is known as a treatment for gout.

Application

• Study for cell division

• Anti-inflammatory agent

• Chemotherapeutic agent

• Therapeutic agent

Reference

• “Addition of colchicine-tubulin complex to microtubule ends: The mechanism of substoichiometric colchicine poisoning”

• “Interactions of colchicine with tubulin”

• “Colchicine Induces Apoptosis in Cerebellar Granule Cells”

Not for human therapeutic use or for medicinal purposes. For research applications only.