Compound 401

SKU
C-2268
  • CAS:168425-64-7
  • Formula:C16H15N3O2
  • MW:281.31
  • Appearance:White to off-white Solid
  • Purity:97% by HPLC
Product Name Qty
Compound 401
5 mg
$187.95

Cell-permeable. A reversible and selective inhibitor of DNA-dependent protein kinase (DNA-PK) (IC= 0.28 M) that also targets mTOR (IC= 5. 3M), but not PI 3-K in vitro. Induces apoptosis in vitro.

More Information
Alternate Name/Synonyms
2-(4-Morpholinyl)-4H-pyrimido[2,1-a]isoquinolin-4-one
SKU
C-2268
CAS #
168425-64-7
Chemical Name
2-(4-Morpholinyl)-4H-pyrimido[2,1-a]isoquinolin-4-one
Chemical Formula
C16H15N3O2
Molecular Weight
281.31
Appearance
White to off-white Solid
Purity
97% by HPLC
Solubility
Soluble in DMSO (10 mM) or EtOH (5 mM)
Melting Point
187.05 °C
Storage Temp
+4°C
THERAPEUTIC AREA
Oncological Disorders
USE
Reversible and selective inhibitor of DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR)
MDL NUMBER
MFCD10568147
CHEMACX
X1763989-1
INCHI
InChI=1S/C16H15N3O2/c20-15-11-14(18-7-9-21-10-8-18)17-16-13-4-2-1-3-12(13)5-6-19(15)16/h1-6,11H,7-10H2
SMILES
C1COCCN1C2=CC(=O)N3C=CC4=CC=CC=C4C3=N2
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Protect from air and light
GHS PICTOGRAMS
Handling Protect from air and light
UN #'S Not Applicable
Packing Group Not Applicable
To Top