Compound E, CpdE

SKU
C-2269
  • CAS:209986-17-4
  • Formula:C27H24F2N4O3
  • MW:490.5
  • Appearance:White to off-white Solid
  • Purity:98% by HPLC
Product Name Qty
Compound E
1 mg
$429.95
Compound E
250 ug
$139.59
Cell-permeable. A potent, selective, non-transition state and non-competitive inhibitor of γ-secretase (IC= 0.3 nM for totalamyloid) and Notch processing. At higher concentrations (20-400 M), only weakly affects the presenilase activity.
More Information
Alternate Name/Synonyms
(2S)-2-([(3,5-Difluorophenyl)acetyl]amino)-N-[(3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]propanamide
SKU
C-2269
CAS #
209986-17-4
Chemical Name
(2S)-2-([(3,5-Difluorophenyl)acetyl]amino)-N-[(3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]propanamide
Chemical Formula
C27H24F2N4O3
Molecular Weight
490.5
Appearance
White to off-white Solid
Purity
98% by HPLC
Solubility
DMSO (~ 10 mg/ml)
Stability
N/A
Storage Temp
-20°C
THERAPEUTIC AREA
Neurological Disorders
USE
A potent and specific inhibitor of γ-secretase use in Alzheimer’s disease
MDL NUMBER
MFCD04974531
CHEMACX
X5572887-1
INCHI
InChI=1S/C27H24F2N4O3/c1-16(30-23(34)14-17-12-19(28)15-20(29)13-17)26(35)32-25-27(36)33(2)22-11-7-6-10-21(22)24(31-25)18-8-4-3-5-9-18/h3-13,15-16,25H,14H2,1-2H3,(H,30,34)(H,32,35)/t16-,25+/m0/s1
SMILES
C[C@@H](C(=O)N[C@@H]1C(=O)N(C2=CC=CC=C2C(=N1)C3=CC=CC=C3)C)NC(=O)CC4=CC(=CC(=C4)F)F
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Protect from light and moisture
Certificate of Analysis 1
Certificate of Analysis 2
Promo text for AGS discount
N/A
GHS PICTOGRAMS
Handling Protect from light and moisture
UN #'S Not Applicable
Packing Group Not Applicable
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