Concanamycin A is an antibiotic and a highly potent and specific cell-permeable inhibitor of V-ATPases that allows to rapidly inactivate this proton pump in living cells. Concanamycin A is more potent specific inhibitor than Bafilomycin A1. Inhibits the acidification of organelles including lysosomes and the Golgi apparatus. Concanamycin A is reported to block cell surface expression of viral glycoproteins without affecting synthesis. Exhibits cytotoxic effects in a number of cell lines in a cell viability assay. Studies have shown that Concanamycin A can cause apoptosis in Human oral squamous carcinoma cells.
Concanamycin A can be used for viral entry studies, it inhibites syncytium formation without affecting glycoprotein synthesis.
Isolated from Streptomyces sp.
|Handling||Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Use with local exhaust ventilation. Handle in accordance with good industrial hygiene and safety practice. Corrosive hazard. Wear protective gloves/clothing and eye/face protection|
|UN #'S||UN 3462|