Concanamycin A

SKU
C-1057
  • CAS:80890-47-7
  • Formula:C46H75NO14
  • MW:866.1 Da
  • Appearance:White Solid
  • Purity:>98%

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Starting at $223.35

Product Name Qty
Concanamycin A, Streptomyces sp.
1 mg
$831.96
Concanamycin A, Streptomyces sp.
100 ug
$223.35

Description

Concanamycin A is an antibiotic and a highly potent and specific cell-permeable inhibitor of V-ATPases that allows to rapidly inactivate this proton pump in living cells. Concanamycin A is more potent specific inhibitor than Bafilomycin A1. Inhibits the acidification of organelles including lysosomes and the Golgi apparatus. Concanamycin A is reported to block cell surface expression of viral glycoproteins without affecting synthesis. Exhibits cytotoxic effects in a number of cell lines in a cell viability assay. Studies have shown that Concanamycin A can cause apoptosis in Human oral squamous carcinoma cells.

Applications:

Concanamycin A can be used for viral entry studies, it inhibites syncytium formation without affecting glycoprotein synthesis.

 

Isolated from Streptomyces sp.

More Information
Alternate Name/Synonyms
Folimycin; ConA; CMA
SKU
C-1057
CAS #
80890-47-7
Chemical Name
[(2R,3S,4R,6R)-6-[(2R,4R,5S,6R)-2-[(2S,3R,4S)-4-[(2R,3S,4E,6E,9R,10S,11S,12R,13R,14E,16Z)-11-ethyl-10,12-dihydroxy-3,17-dimethoxy-7,9,13,15-tetramethyl-18-oxo-1-oxacyclooctadeca-4,6,14,16-tetraen-2-yl]-3-hydroxypentan-2-yl]-2-hydroxy-5-methyl-6-[(E)-prop-
Chemical Formula
C46H75NO14
Molecular Weight
866.1 Da
Appearance
White Solid
Purity
>98%
Solubility
Soluble in DSMO
Melting Point
N/A
Preparation
N/A
Storage Temp
-20°C, desiccated
THERAPEUTIC AREA
Not Available
USE
Concanamycin A, also designated folimycin, is an antibiotic and well-noted specific inhibitor of V-ATPase (vacuolar type H+-ATPase) activity. Concanamycin A is also capable of inducing cell-death through apoptosis, able to inhibit perforin-based cytotoxic activity in CD8+ T cells, and to inhibit intracellular protein trafficking in both plant and animal cells. As an inhibitor of V-ATPase, concanamycin has been reported to induce cell death via apoptosis in WEHI 231, SP2/0-Ag14 cells lines as well as mouse hybridomas. The inhibition of perforin-based cytotoxic activity in CD8+ CTL clone OE4 was reported to be selective for completely blocking perforin-based cytotoxic activity in these clones. Additionally, concanamycin A was noted to lead to reversible vacuolation of the Golgi apparatus in tobacco BY-2 cells, indicating potential interference with protein trafficking in this cell line.
Merck Index
N/A
MDL NUMBER
MFCD00210037
CHEMACX
X1088871-6
INCHI
InChI=1S/C46H75NO14/c1-13-16-34-28(7)37(58-38-22-33(48)43(31(10)57-38)60-45(47)53)23-46(54,61-34)30(9)41(51)29(8)42-35(55-11)18-15-17-24(3)19-26(5)39(49)32(14-2)40(50)27(6)20-25(4)21-36(56-12)44(52)59-42/h13,15-18,20-21,26-35,37-43,48-51,54H,14,19,22-23H2,1-12H3,(H2,47,53)/b16-13+,18-15+,24-17+,25-20+,36-21-/t26-,27-,28-,29+,30+,31-,32+,33-,34-,35+,37-,38+,39+,40-,41-,42-,43-,46-/m1/s1
SMILES
CC[C@H]1[C@H]([C@@H](C/C(=C/C=C/[C@@H]([C@H](OC(=O)/C(=C/C(=C/[C@H]([C@H]1O)C)/C)/OC)[C@@H](C)[C@H]([C@H](C)[C@]2(C[C@H]([C@@H]([C@H](O2)/C=C/C)C)O[C@H]3C[C@H]([C@@H]([C@H](O3)C)OC(=O)N)O)O)O)OC)/C)C)O
Peptide sequence
Not Applicable
RTECS
CB9732000
UN #'S
UN 3462
PACKING GROUP
II
HAZARD CLASS
Not Applicable
Handling
Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Use with local exhaust ventilation. Handle in accordance with good industrial hygiene and safety practice. Corrosive hazard. Wear protective gloves/clothing and eye/face protection
Certificate of Analysis 1
Certificate of Analysis 2
Certificate of Analysis 3
GHS PICTOGRAMS
Handling Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Use with local exhaust ventilation. Handle in accordance with good industrial hygiene and safety practice. Corrosive hazard. Wear protective gloves/clothing and eye/face protection
UN #'S UN 3462
Packing Group II
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