- MW:851.5 Da
- Appearance:White solid
- Purity:>95% by HPLC
Concanamycin B is a macrocyclic lactone originally isolated from Streptomyces diastatochromogenes in 1982 as a potent inhibitor of the proliferation of mouse splenic lymphocytes stimulated by concanavalin A. Like other concanamycins and bafilomycins, concanamycin B inhibits vacuolar H(+)-ATPase. Concanamycin B inhibits the expression of newly-synthesized MHC class II molecules and suppresses bone resorption in vitro.
• Structures of concanamycins B and C. Kinashi H. et al., J. Antibiot. 1982, 35, 1618.
• Concanamycin B, a vacuolar H(+)-ATPase specific inhibitor suppresses bone resorption in vitro. Woo J.T. et al., Biol. Pharm. Bull. 1996, 19, 297.
• Concanamycin B inhibits the expression of newly-synthesized MHC class II molecules on the cell surface. Ito K. et al., J. Antibiot. 1995, 48, 488.
|Handling||Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Use with local exhaust ventilation. Corrosive hazard. Wear protective gloves/clothing and eye/face protection.|