Concanavalin A Lectin

SKU
C-1662
  • CAS:11028-71-0
  • MW:104 kDa
  • Appearance:Lyophilized powder
  • Purity:≥95%
Product Name Qty
Concanavalin A
250 mg
$188.70
Concanavalin A
1 g
$501.19
Concanavalin A
50 mg
$96.90

Description

Concanavalin A, sometimes abbreviated as Con A, is a mitogenic lectin derived from the jack bean plant (Canavalia ensiformis). Concanavalin A has a strong affinity for carbohydrates in dimeric and higher forms, as well as an affinity for glycolipids and glycoproteins. This lectin requires metal ions Ca2+ and Mn2+ for saccharide binding and has greatest activity at pH 7.

Research into concanavalin A has focused heavily on its potential anticancer effects due to mitogenic activity with lymphocytes and cancer cells. In particular, this lectin is known to target hepatomas. When administered, concanavalin A binds to glycoproteins of the cell membrane, inducing autophagy when it eventually enters the cell. Simultaneously, it triggers inflammation of tumorous cells, causing an immune response targeted against those cells. This simultaneous induction of immune response and autophagy makes it a potentially potent and novel cancer treatment. It is also used for studies of immune regulation across various cell types. 

Applications

• Affinity chromatography purifications and characterization of various glycoproteins and cell structures
• Purification of glycosylated macromolecules in Lectin Affinity Chromatography
• Studies of immune regulation by various immune cells
• Induces autophagy
• Induces apoptosis in human fibroblasts

Specifications

• Salt-free

 

More Information
Alternate Name/Synonyms
ConA
SKU
C-1662
CAS #
11028-71-0
Molecular Weight
104 kDa
Appearance
Lyophilized powder
Purity
≥95%
Solubility
Water soluble
Storage Temp
-20°C
THERAPEUTIC AREA
Not Applicable
USE
Concanavalin A Lectin is isolated from Canavalia ensiformis and is purified by affinity chromatography. It has been used in the colabelling of fischer rat thyroid epithelia. It may induce autoimmune hepatitis in Cre-conditional atg7 knockout mice and detect glycoproteins containing α-D-mannose, α-D-glucose when used with avidin or streptavidin detection system. There are studies of Concanavalin A Lectin interaction with locust muscle fibers, adipocytes, and rat liver plasma membrane components. It induces endoreduplication in mammalian cells and it reacts with E. coli, Bacillus lipopolysaccharides and Dictyostelium discoideum.
Merck Index
14, 2495
Handling
Avoid contact with skin, eyes or clothing. Wash contaminated clothing before reuse. Do not eat, drink or smoke when using this product. Use personal protective equipment as required. Do not breathe dust/fume/gas/mist/vapors/spray.
GHS PICTOGRAMS
HandlingAvoid contact with skin, eyes or clothing. Wash contaminated clothing before reuse. Do not eat, drink or smoke when using this product. Use personal protective equipment as required. Do not breathe dust/fume/gas/mist/vapors/spray.
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