CP-31398 Dihydrochloride

SKU

C-2270

CAS:259199-65-0
Formula:C₂₂H₂₆N₄O.₂HCl
MW:435.39
Appearance:Yellow Solid
Purity:98% by TLC

SDS

CofA

Product Name	Qty
CP-31398 Dihydrochloride 5 mg $100.25
CP-31398 Dihydrochloride 25 mg $398.67

Details

A styrylquinazoline derivative that acts as a p53 stabilizing agent. It not only restores p53 functions in mutant p53-expressing cells but can also significantly increase the protein level and promote the activity of wild-type p53 in multiple human cancer cell lines, leading to cell cycle arrest or apoptosis. CP-31398 enhances the protein levels of wild-type p53 by blockade of ubiquitination and degradation of p53 without interrupting the physical association between p53 and MDM2 in vivo.

Specifications

More Information

Alternate Name/Synonyms

N'-[2-[2-(4-Methoxyphenyl)ethenyl]-4-quinazolinyl]-N,N-dimethyl-1,3-propanediamine Dihydrochloride

SKU

C-2270

CAS #

259199-65-0

Chemical Name

N'-[2-[2-(4-Methoxyphenyl)ethenyl]-4-quinazolinyl]-N,N-dimethyl-1,3-propanediamine Dihydrochloride

Chemical Formula

C₂₂H₂₆N₄O.₂HCl

Molecular Weight

435.39

Appearance

Yellow Solid

Purity

98% by TLC

Solubility

Soluble in H₂O (25 mg/ml) or DMSO (5 mg/ml)

Storage Temp

-20°C

THERAPEUTIC AREA

Oncological Disorders

USE

CP 31398 dihydrochloride restores mutant p53 tumor suppressor function and inhibits UVB-induced skin cancer

MDL NUMBER

MFCD11519956

CHEMACX

X1763944-2

INCHI

InChI=1S/C22H26N4O.2ClH/c1-26(2)16-6-15-23-22-19-7-4-5-8-20(19)24-21(25-22)14-11-17-9-12-18(27-3)13-10-17;;/h4-5,7-14H,6,15-16H2,1-3H3,(H,23,24,25);2*1H/b14-11+;;

SMILES

CN(C)CCCNC1=NC(=NC2=CC=CC=C21)/C=C/C3=CC=C(C=C3)OC.Cl.Cl

Peptide sequence

Not Applicable

RTECS

Not Applicable

UN #'S

Not Applicable

PACKING GROUP

Not Applicable

HAZARD CLASS

Not Applicable