SDS
CofA
A styrylquinazoline derivative that acts as a p53 stabilizing agent. It not only restores p53 functions in mutant p53-expressing cells but can also significantly increase the protein level and promote the activity of wild-type p53 in multiple human cancer cell lines, leading to cell cycle arrest or apoptosis. CP-31398 enhances the protein levels of wild-type p53 by blockade of ubiquitination and degradation of p53 without interrupting the physical association between p53 and MDM2 in vivo.
More Information
Alternate Name/Synonyms
N'-[2-[2-(4-Methoxyphenyl)ethenyl]-4-quinazolinyl]-N,N-dimethyl-1,3-propanediamine Dihydrochloride
SKU
C-2270
CAS #
259199-65-0
Chemical Name
N'-[2-[2-(4-Methoxyphenyl)ethenyl]-4-quinazolinyl]-N,N-dimethyl-1,3-propanediamine Dihydrochloride
Chemical Formula
C22H26N4O.2HCl
Molecular Weight
435.39
Appearance
Yellow Solid
Purity
98% by TLC
Solubility
Soluble in H2O (25 mg/ml) or DMSO (5 mg/ml)
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
CP 31398 dihydrochloride restores mutant p53 tumor suppressor function and inhibits UVB-induced skin cancer
MDL NUMBER
MFCD11519956
CHEMACX
X1763944-2
INCHI
InChI=1S/C22H26N4O.2ClH/c1-26(2)16-6-15-23-22-19-7-4-5-8-20(19)24-21(25-22)14-11-17-9-12-18(27-3)13-10-17;;/h4-5,7-14H,6,15-16H2,1-3H3,(H,23,24,25);2*1H/b14-11+;;
SMILES
CN(C)CCCNC1=NC(=NC2=CC=CC=C21)/C=C/C3=CC=C(C=C3)OC.Cl.Cl
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Protect from light and moisture
| GHS PICTOGRAMS |  |
|---|---|
| Handling | Protect from light and moisture |
| UN #'S | Not Applicable |
| Packing Group | Not Applicable |
