Crizotinib

SKU
C-2272
  • CAS:877399-52-5
  • Formula:C21H22Cl2FN5O
  • MW:450.34
  • Appearance:Off-White Solid
  • Purity:98% by HPLC

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Product Name Qty
Crizotinib
25 mg
$300.00
Crizotinib
5 mg
$100.00
A specific, ATP-competitive, small-molecule inhibitor of the receptor tyrosine kinases (RTKs) c-Met and anaplastic lymphoma kinase (ALK). Iinhibits tyrosine phosphorylation of activated ALK at nanomolar concentrations. Inhibits the growth and survival of cell lines dependent upon c-Met or ALK enzymatic activity.
More Information
Alternate Name/Synonyms
3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine
SKU
C-2272
CAS #
877399-52-5
Chemical Name
3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine
Chemical Formula
C21H22Cl2FN5O
Molecular Weight
450.34
Appearance
Off-White Solid
Purity
98% by HPLC
Solubility
DMSO
Melting Point
202-204 °C
Storage Temp
-20°C
THERAPEUTIC AREA
Oncological Disorders
USE
Crizotinib is an anti-cancer drug acting as an ALK (anaplastic lymphoma kinase) and ROS1 (c-ros oncogene 1) inhibitor for treatment of some non-small cell lung carcinoma
MDL NUMBER
MFCD12407409
CHEMACX
X1759586-1
INCHI
InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1
SMILES
C[C@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
UN 3077
PACKING GROUP
III
HAZARD CLASS
Not Applicable
Handling
Protect from air and light
GHS PICTOGRAMS
Handling Protect from air and light
UN #'S UN 3077
Packing Group III
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