iCRT5 (CRT Inhibitor)
SKU
C-2273
- CAS:18623-44-4
- Formula:C16H17NO5S2
- MW:367.44 Da
- Appearance:Yellow Solid
- Purity:≥98% (HPLC)
SDS
CofA
Description
A cell-permeable, potent inhibitor of Beta-catenin-responsive transcription (CRT) in the nucleus. iCRT5 inhibits Wnt responsive STF16 luciferase (STF16-Luc) with an ICof 18 nM. It acts by disrupting the interaction betweencatenin and TCF4, possibly by direct binding to Beta-catenin. However, it displays minimal or less prominent effect on non-canonical Wnt signaling and other pathways such as Hh, JAK/STAT, and Notch signaling.
Applications
• Beta-catenin inhibitor
More Information
Alternate Name/Synonyms
4-[5-(3,4-Dimethoxy-benzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl]-butyric acid
SKU
C-2273
CAS #
18623-44-4
Chemical Name
4-[(5Z)-5-[(3,4-dimethoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanoic acid
Chemical Formula
C16H17NO5S2
Molecular Weight
367.44 Da
Appearance
Yellow Solid
Purity
≥98% (HPLC)
Solubility
Soluble in DMSO (10 mg/mL), methanol (40 mg/mL), 0.1N sodium hydroxide (50 mg/mL) or acetic acid (camptothecin)
Melting Point
N/A
Preparation
N/A
Storage Temp
-20°C
THERAPEUTIC AREA
Not Applicable
USE
iCRT5 is a selective CRT (β-catenin-responsive transcription) inhibitor. It acts by disrupting the interaction between beta-catenin and TCF4, possibly by direct binding to beta-catenin. However, it displays minimal or less prominent effect on non-canonical Wnt signaling and other pathways such as Hh, JAK/STAT, and Notch signaling.
Merck Index
N/A
MDL NUMBER
MFCD00703657
CHEMACX
X1474972-7
PubChecm ID
1416325
INCHI
InChI=1S/C16H17NO5S2/c1-21-11-6-5-10(8-12(11)22-2)9-13-15(20)17(16(23)24-13)7-3-4-14(18)19/h5-6,8-9H,3-4,7H2,1-2H3,(H,18,19)/b13-9-
SMILES
COC1=C(C=C(C=C1)/C=C\2/C(=O)N(C(=S)S2)CCCC(=O)O)OC
Handling
Protect from air and light. Handle in accordance with good industrial hygiene and safety practice.
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| Handling | Protect from air and light. Handle in accordance with good industrial hygiene and safety practice. |