iCRT5 (CRT Inhibitor)

SKU
C-2273
  • CAS:18623-44-4
  • Formula:C16H17NO5S2
  • MW:367.44 Da
  • Appearance:Yellow Solid
  • Purity:≥98% (HPLC)

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Product Name Qty
CRT Inhibitor, iCRT5
25 mg
$346.28
CRT Inhibitor, iCRT5
5 mg
$91.98

Description

A cell-permeable, potent inhibitor of Beta-catenin-responsive transcription (CRT) in the nucleus. iCRT5 inhibits Wnt responsive STF16 luciferase (STF16-Luc) with an ICof 18 nM. It acts by disrupting the interaction betweencatenin and TCF4, possibly by direct binding to Beta-catenin. However, it displays minimal or less prominent effect on non-canonical Wnt signaling and other pathways such as Hh, JAK/STAT, and Notch signaling.

 

Applications

• Beta-catenin inhibitor

 

More Information
Alternate Name/Synonyms
4-[5-(3,4-Dimethoxy-benzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl]-butyric acid
SKU
C-2273
CAS #
18623-44-4
Chemical Name
4-[(5Z)-5-[(3,4-dimethoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanoic acid
Chemical Formula
C16H17NO5S2
Molecular Weight
367.44 Da
Appearance
Yellow Solid
Purity
≥98% (HPLC)
Solubility
Soluble in DMSO (10 mg/mL), methanol (40 mg/mL), 0.1N sodium hydroxide (50 mg/mL) or acetic acid (camptothecin)
Melting Point
N/A
Preparation
N/A
Storage Temp
-20°C
THERAPEUTIC AREA
Not Applicable
USE
iCRT5 is a selective CRT (β-catenin-responsive transcription) inhibitor. It acts by disrupting the interaction between beta-catenin and TCF4, possibly by direct binding to beta-catenin. However, it displays minimal or less prominent effect on non-canonical Wnt signaling and other pathways such as Hh, JAK/STAT, and Notch signaling.
Merck Index
N/A
MDL NUMBER
MFCD00703657
CHEMACX
X1474972-7
PubChecm ID
1416325
INCHI
InChI=1S/C16H17NO5S2/c1-21-11-6-5-10(8-12(11)22-2)9-13-15(20)17(16(23)24-13)7-3-4-14(18)19/h5-6,8-9H,3-4,7H2,1-2H3,(H,18,19)/b13-9-
SMILES
COC1=C(C=C(C=C1)/C=C\2/C(=O)N(C(=S)S2)CCCC(=O)O)OC
Handling
Protect from air and light. Handle in accordance with good industrial hygiene and safety practice.
GHS PICTOGRAMS
Handling Protect from air and light. Handle in accordance with good industrial hygiene and safety practice.
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