Curvularin

SKU
C-2675
  • CAS:10140-70-2
  • Formula:C16H20O5
  • MW:292.3
  • Appearance:White solid
  • Purity:>99% by HPLC
Product Name Qty
Curvularin
1 mg
$64.05
Curvularin
5 mg
$250.86

Curvularin is a 12-membered macrocyclic lactone incorporating a resorcinyl moiety, produced by a number of fungal species including Curvularia, Penicillium and Alternaria. Curvularin exhibits a distinctly different biological profile to the structurally similar resorcylic acid lactones such as the zearalenones, radicicol and LL Z1640-2. Curvularin inhibits cell division by disrupting mitotic spindle formation and is known to be phytotoxic. More recent investigations have shown that curvularin is a highly selective transcription-based inhibitor of iNOS-dependent NO production, acting on the Janus tyrosine kinase-STAT pathway. This action offers an approach to the development of drugs inhibiting iNOS overproduction associated with NO pathophysiology.

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More Information
Alternate Name/Synonyms
S-Curvularin, NSC 166071
SKU
C-2675
CAS #
10140-70-2
Chemical Formula
C16H20O5
Molecular Weight
292.3
Appearance
White solid
Purity
>99% by HPLC
Solubility
Soluble in methanol, dioxane, pyridine
Storage Temp
-20°C
USE
A potent antifungal and mycotoxin that also inhibits NO production
MDL NUMBER
MFCD09752718
INCHI
InChI=1S/C16H20O5/c1-10-5-3-2-4-6-13(18)16-11(8-15(20)21-10)7-12(17)9-14(16)19/h7,9-10,17,19H,2-6,8H2,1H3/t10-/m0/s1
SMILES
C[C@H]1CCCCCC(=O)c2c(cc(cc2O)O)CC(=O)O1
Promo text for AGS discount
N/A
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