Cycloheximide

SKU
C-1189
  • CAS:66-81-9
  • Formula:C15H23NO4
  • MW:281.35 Da
  • Appearance:White or cream color powder
  • Purity:≥95.0%

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Product Name Qty
Cycloheximide
50 g
$625.46
Cycloheximide
1 g
$44.13
Cycloheximide
25 g
$362.93
Cycloheximide
5 g
$95.70
Cycloheximide
10 g
$155.23

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Description

Cycloheximide is an antibiotic produced by Streptomyces sp. that activates against yeasts and fungi. It inhibits protein synthesis thru DNA translation arrest in eukaryotes. Cycloheximide also inhibits chain initiation and chain elongation by acting on 60S subunits of eukaryote ribosome.

Applications

• Used as an inhibitor to study cell-free protein biosynthesis in eukaryotes
• Used to block ribosome-dependent in vivo polypeptide synthesis
• Used in genome editing utilizing the CRISPR/Cas9 system
• Used to clear macrophages in atherosclerotic plaques
• Used to activate cumulus-free equine oocytes, and to have neuroprotective properties

Cycloheximide is in stock. Call for bulk quotations, typical lead for subdivision, packing and shipping larger quantities is 7-14 days. Research size order 100mg 250mg lead is shorter.

 

More Information
Alternate Name/Synonyms
Actidione; Naramycin A; Kaken; Hizarocin; Zykloheximid; Neocycloheximide; Acti-Aid; Actispray
SKU
C-1189
CAS #
66-81-9
Chemical Name
4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione
Chemical Formula
C15H23NO4
Molecular Weight
281.35 Da
Appearance
White or cream color powder
Purity
≥95.0%
Solubility
Soluble in Chloroform, Ethanol and Methanol
Preparation
Store solutions at -20°C
Storage Temp
+4°C, desiccated
THERAPEUTIC AREA
Infectious diseases
USE
Cycloheximide is a highly effective antibiotic with activity against mold, yeast, and phytopathogenic fungi, with lower activity against bacteria. It has been reported to inhibit the synthesis of both proteins and macromolecules, as well as affect apoptosis in eukaryotes. Inhibition of protein synthesis is believed to be mediated through DNA translation arrest, as demonstrated in rat thymocytes. Although cycloheximide has been reported to induce apoptosis in various cells, it has also been shown to inhibit or delay induced apoptosis. These observations suggest that cycloheximide's effect on apoptosis may not be solely through protein translation arrest and that other mechanisms may be involved. Cycloheximide has also been reported to inhibit FKBP12 (peptidylprolylisomerase hFKBP12, PPIase hFKBP12) via competitive inhibition.
MDL NUMBER
MFCD00082346
CHEMACX
X1006248-5
INCHI
InChI=1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1
SMILES
C[C@H]1C[C@@H](C(=O)[C@@H](C1)[C@@H](CC2CC(=O)NC(=O)C2)O)C
Peptide sequence
Not Applicable
RTECS
MA4375000
UN #'S
UN 2811
PACKING GROUP
I
HAZARD CLASS
Not Applicable
Handling
Avoid contact with skin, eyes or clothing. Wash contaminated clothing before reuse. Do not eat, drink or smoke when using this product. Use personal protective equipment as required. Do not breathe dust/fume/gas/mist/vapors/spray. Use with local exhaust ventilation. Corrosive hazard. Wear protective gloves/clothing and eye/face protection.
Certificate of Analysis 1
Certificate of Analysis 2
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GHS PICTOGRAMS
Handling Avoid contact with skin, eyes or clothing. Wash contaminated clothing before reuse. Do not eat, drink or smoke when using this product. Use personal protective equipment as required. Do not breathe dust/fume/gas/mist/vapors/spray. Use with local exhaust ventilation. Corrosive hazard. Wear protective gloves/clothing and eye/face protection.
UN #'S UN 2811
Packing Group I
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Regulation of protein and mRNA expression of the mTORC1 repressor REDD1 in response to leucine and serum
Interaction of the polyglutamine protein ataxin-3 with Rad23 regulates toxicity in Drosophila models of Spinocerebellar Ataxia Type 3
The eIF2 alpha Kinases GCN2 and PERK Regulate Phosphorylation of TOR Target Proteins and Differential Translation of mRNAs
Utilizing a Microbial Natural Product to Investigate Cellular Circuitry Governing Fungal Drug Resistance and Morphogenesis
Type I Interferon Mediates Th2 Reprogramming and Acute Suppression of Effector Functions
Role of glycogen synthase kinase 3β in rapamycin-mediated cell cycle regulation and chemosensitivity
Mycological Characteristics of Ophiostoma quercus, a Sap-staining Fungus Isolated from Japanese Black Pine in Korea
Detection and phylogenetic analysis of Coccidioides posadasii in Arizona soil samples
The potential roles of c-Jun N-terminal kinase (JNK) during the maturation and aging of oocytes produced by a marine protostome worm
AXL degradation in combination with EGFR-TKI can delay and overcome acquired resistance in human non-small cell lung cancer cells
Differential toxicity of ataxin-3 isoforms in Drosophila models of Spinocerebellar Ataxia Type 3
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