Cyclopamine-KAAD

SKU
C-2277
  • CAS:306387-90-6
  • Formula:C44H63N3O4
  • MW:697.99
  • Appearance:Pale yellow Solid
  • Purity:80% by HPLC

0

1

0

0

Product Name Qty
Cyclopamine-KAAD
50 ug
$134.41
Cell-permeable. A synthetic derivative of the natural product Cyclopamine (Cat. No. 1578-5) that acts as a specific inhibitor of Smoothened (Smo) and Sonic hedgehog (Shh) intracellular signaling (IC=20 nM in the Shh-LIGHT2 assay).
More Information
Alternate Name/Synonyms
3-Keto-N-(aminoethyl-N-aminocaproyldihydrocinnamoyl)cyclopamine; KAAD-cyclopamine
SKU
C-2277
CAS #
306387-90-6
Chemical Name
3-KETO-N-AMINOETHYL-N'-AMINOCAPROYLDIHYDROCINNAMOYL CYCLOPAMINE
Chemical Formula
C44H63N3O4
Molecular Weight
697.99
Appearance
Pale yellow Solid
Purity
80% by HPLC
Solubility
Soluble in DMSO or EtOH
Storage Temp
-20°C
THERAPEUTIC AREA
Not Available
USE
Cyclopamine-KAAD is a potent, cell-permeable analog of Cyclopamine that specifically inhibits the Hedgehog (Hh) signaling with similar or lower toxicity
MDL NUMBER
MFCD03425585
CHEMACX
Not Applicable
INCHI
InChI=1S/C44H63N3O4/c1-29-25-39-42(47(28-29)24-23-46-40(49)13-9-6-10-22-45-41(50)17-14-32-11-7-5-8-12-32)31(3)44(51-39)21-19-35-36-16-15-33-26-34(48)18-20-43(33,4)38(36)27-37(35)30(44)2/h5,7-8,11-12,15,29,31,35-36,38-39,42H,6,9-10,13-14,16-28H2,1-4H3,(H,45,50)(H,46,49)
SMILES
CC1CC2C(C(C3(O2)CCC4C5CC=C6CC(=O)CCC6(C5CC4=C3C)C)C)N(C1)CCNC(=O)CCCCCNC(=O)CCc7ccccc7
Peptide sequence
Not Applicable
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
Protect from air and moisture
GHS PICTOGRAMS
Handling Protect from air and moisture
UN #'S Not Applicable
Packing Group Not Applicable
To Top