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Cyclosporin A

SKU
C-1199
  • CAS:59865-13-3
  • Formula:C62H111N11O12
  • MW:1202.6 Da
  • Appearance:White powder
  • Purity:>98% (HPLC)
Product Name Qty
Cyclosporin A, Fusarium solani
100 mg
$57.38
Cyclosporin A, Fusarium solani
500 mg
$208.68
Cyclosporin A, Fusarium solani
1 g
$313.04
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Potent immunosuppressor. Inhibitor of the mitochondrial permeability transition pore (MPTP), preventing necrosis in several models. Isolated from Fusarium solani. Mitochondria are the primary target in isothiocyanate-induced apoptosis in human bladder cancer cells. The Influence of B-Cell Lymphoma 2 Protein, an Antiapoptotic Regulator of Mitochondrial Permeability Transition, on Isoflurane-Induced and Ischemic Postconditioning in Rabbits.Delineating the mechanism by which selenium deactivates Akt in prostate cancer cells.

More Information
Alternate Name/Synonyms
Ciclosporin; Ciclosporine; Cyclosporine; Cyclosporine A; Ramihyphin A; Antibiotic S 7481F1; NSC 290193; CsA
SKU
C-1199
CAS #
59865-13-3
Chemical Name
(3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17
Chemical Formula
C62H111N11O12
Molecular Weight
1202.6 Da
Appearance
White powder
Purity
>98% (HPLC)
Solubility
Soluble inDMSO (25 mg/mL), methanol, 100% ethanol (25 mg/mL), or acetone. Insoluble in water.
Storage Temp
-20°C
THERAPEUTIC AREA
Autoimmune Diseases
USE
Cyclosporine A is an immunosuppressant drug widely used in organ transplantation to prevent rejection
MDL NUMBER
MFCD00274558
CHEMACX
X1005487-8
INCHI
PMATZTZNYRCHOR-CGLBZJNRSA-N
SMILES
CC[C@H]1C(=O)N(CC(=O)N([C@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N1)[C@@H]([C@H](C)C/C=C/C)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C
RTECS
GZ4120000
Handling
Warning. Toxic. Wear gloves/mask when handling product. Avoid contact by all means of exposure.
Certificate of Analysis 1
C-1199, E1043.pdf
GHS PICTOGRAMS
HandlingWarning. Toxic. Wear gloves/mask when handling product. Avoid contact by all means of exposure.
CitationsRegulator of Calcineurin 1 Isoform 4 (RCAN1.4) Is Overexpressed in the Glomeruli of Diabetic Mice
Cellular accumulation of dietary anticarcinogenic isothiocyanates is followed by transporter-mediated export as dithiocarbamates
Delineating the mechanism by which selenium deactivates Akt in prostate cancer cells
The influence of B-cell lymphoma 2 protein, an antiapoptotic regulator of mitochondrial permeability transition, on isoflurane-induced and ischemic postconditioning in rabbits
Synapsin regulates vesicle organization and activity-dependent recycling at Drosophila motor boutons
Synapsin maintains the reserve vesicle pool and spatial segregation of the recycling pool in Drosophila presynaptic boutons
Graft-versus-host disease is enhanced by extracellular ATP activating P2X7R
Calcineurin serves in the circadian output pathway to regulate the daily rhythm of L-type voltage-gated calcium channels in the retina
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