Search
My Cart

Cyclosporin A

SKU
C-1199
  • CAS:59865-13-3
  • Formula:C62H111N11O12
  • MW:1202.6 Da
  • Appearance:White powder
  • Purity:>98% (HPLC)

1

0

0

SDS
CofA
Product Name Qty
Cyclosporin A, Fusarium solani
100 mg
$56.09
Cyclosporin A, Fusarium solani
1 g
$306.00
Cyclosporin A, Fusarium solani
500 mg
$203.99
Add to Compare Email
Loading...

Potent immunosuppressor. Inhibitor of the mitochondrial permeability transition pore (MPTP), preventing necrosis in several models. Isolated from Fusarium solani. Mitochondria are the primary target in isothiocyanate-induced apoptosis in human bladder cancer cells. The Influence of B-Cell Lymphoma 2 Protein, an Antiapoptotic Regulator of Mitochondrial Permeability Transition, on Isoflurane-Induced and Ischemic Postconditioning in Rabbits.Delineating the mechanism by which selenium deactivates Akt in prostate cancer cells.

More Information
Alternate Name/Synonyms
Ciclosporin; Ciclosporine; Cyclosporine; Cyclosporine A; Ramihyphin A; Antibiotic S 7481F1; NSC 290193; CsA
SKU
C-1199
CAS #
59865-13-3
Chemical Name
(3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17
Chemical Formula
C62H111N11O12
Molecular Weight
1202.6 Da
Appearance
White powder
Purity
>98% (HPLC)
Solubility
Soluble inDMSO (25 mg/mL), methanol, 100% ethanol (25 mg/mL), or acetone. Insoluble in water.
Storage Temp
-20°C
THERAPEUTIC AREA
Autoimmune Diseases
USE
Cyclosporine A is an immunosuppressant drug widely used in organ transplantation to prevent rejection
MDL NUMBER
MFCD00274558
CHEMACX
X1005487-8
INCHI
PMATZTZNYRCHOR-CGLBZJNRSA-N
SMILES
CC[C@H]1C(=O)N(CC(=O)N([C@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N1)[C@@H]([C@H](C)C/C=C/C)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C
RTECS
GZ4120000
Handling
Warning. Toxic. Wear gloves/mask when handling product. Avoid contact by all means of exposure.
Certificate of Analysis 1
C-1199, E1043.pdf
GHS PICTOGRAMS
Handling Warning. Toxic. Wear gloves/mask when handling product. Avoid contact by all means of exposure.
Citations Regulator of Calcineurin 1 Isoform 4 (RCAN1.4) Is Overexpressed in the Glomeruli of Diabetic Mice
Cellular accumulation of dietary anticarcinogenic isothiocyanates is followed by transporter-mediated export as dithiocarbamates
Delineating the mechanism by which selenium deactivates Akt in prostate cancer cells
The influence of B-cell lymphoma 2 protein, an antiapoptotic regulator of mitochondrial permeability transition, on isoflurane-induced and ischemic postconditioning in rabbits
Synapsin regulates vesicle organization and activity-dependent recycling at Drosophila motor boutons
Synapsin maintains the reserve vesicle pool and spatial segregation of the recycling pool in Drosophila presynaptic boutons
Graft-versus-host disease is enhanced by extracellular ATP activating P2X7R
Calcineurin serves in the circadian output pathway to regulate the daily rhythm of L-type voltage-gated calcium channels in the retina
We found other products you might like!
To Top