Cyclosporin D

SKU

C-2699

CAS:63775-96-2
Formula:C₆₃H₁₁₃N₁₁O₁₂
MW:1216.7 Da
Appearance:White powder
Purity:>95% by HPLC

SDS

CofA

Product Name	Qty
Cyclosporin D 5 mg $517.14
Cyclosporin D 1 mg $148.07

Details

Description

Cyclosporin D is a minor analogue of the cyclosporin family which is only weakly immunologically active. Cyclosporin D is a potent inhibitor of tumor-promoting phorbol esters on mouse skin in vivo, and a potent inhibitor of calcium/calmodulin-dependent EF-2 phosphorylation in vitro.

Specifications

More Information

Alternate Name/Synonyms

7-L-valinecyclosporine A

SKU

C-2699

CAS #

63775-96-2

Chemical Name

3S,6S,9S,12R,15S,18S,21S,24S,30S)-33-((1R,2R,E)-1-hydroxy-2-methylhex-4-en-1-yl)-6,9,18,24-tetraisobutyl-3,21,30-triisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25

Chemical Formula

C₆₃H₁₁₃N₁₁O₁₂

Molecular Weight

1216.7 Da

Appearance

White powder

Purity

>95% by HPLC

Solubility

Soluble in 100% ethanol, acetone or ethyl acetate; insoluble in water

Storage Temp

4°C

USE

Cyclosporin D is a metabolite of cyclosporin A

MDL NUMBER

MFCD00907207

INCHI

InChI=1S/C63H113N11O12/c1-26-27-41(16)53(76)52-57(80)67-50(39(12)13)62(85)68(19)33-49(75)69(20)44(28-34(2)3)56(79)66-51(40(14)15)63(86)70(21)45(29-35(4)5)55(78)64-42(17)54(77)65-43(18)58(81)71(22)46(30-36(6)7)59(82)72(23)47(31-37(8)9)60(83)73(24)48(32-38(10)11)61(84)74(52)25/h26-27,34-48,50-53,76H,28-33H2,1-25H3,(H,64,78)(H,65,77)(H,66,79)(H,67,80)/b27-26+/t41-,42+,43-,44-,45-,46+,47-,48+,50-,51+,52+,53+/m0/s1

SMILES

C/C=C/[C@H](C)[C@H]([C@@H]1C(=O)N[C@H](C(=O)N(CC(=O)N([C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N([C@@H](C(=O)N([C@H](C(=O)N([C@@H](C(=O)N1C)CC(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C)C(C)C)O

Handling

Use only in area provided with appropriate exhaust ventilation. Keep away from heat and source of ignition. Empty containers pose a fire risk, evaporate residue under fume hood. Ground all equipment containing material. Do not breathe dust.

Reviews

Safety

GHS PICTOGRAMS
Handling	Use only in area provided with appropriate exhaust ventilation. Keep away from heat and source of ignition. Empty containers pose a fire risk, evaporate residue under fume hood. Ground all equipment containing material. Do not breathe dust.

Citations