Cyclosporin H, CsH

SKU
C-1666
  • CAS:83602-39-5
  • Formula:C62H111N11O12
  • MW:1202.6 Da
  • Appearance:White to off-white powder
  • Purity:>95% by HPLC

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Starting at $140.00

Product Name Qty
Cyclosporin H
1 mg
$140.00
Cyclosporin H
5 mg
$500.00

Description

Cyclosporin H is a minor analogue of the cyclosporin family which is immunologically inactive as it does not bind to immunophilin. Cyclosporin H is the most extensively investigated of the minor cyclosporin analogues . It is a potent inhibitor of tumor-promoting phorbol esters on mouse skin in vivo, and of calcium/calmodulin-dependent EF-2 phosphorylation in vitro, a potent and selective antagonist of formyl peptide receptor and inhibitor of formyl peptide-induced superoxide formation.

 

More Information
Alternate Name/Synonyms
Csh-cyclosporin; 5-(N-Methyl-D-valine)-cyclosporin A; CsH
SKU
C-1666
CAS #
83602-39-5
Chemical Name
5-(N-Methyl-D-valine)-cyclosporin A
Chemical Formula
C62H111N11O12
Molecular Weight
1202.6 Da
Appearance
White to off-white powder
Purity
>95% by HPLC
Solubility
Soluble in 100% ethanol, acetone or ethyl acetate. Insoluble in water.
Melting Point
148-151 °C
Storage Temp
-20°C
THERAPEUTIC AREA
Not Available
USE
For laboratory and research purposes only.
MDL NUMBER
MFCD04039488
CHEMACX
X1407182-4
INCHI
InChI=1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50-,51+,52-/m1/s1
SMILES
CC[C@H]1C(=O)N(CC(=O)N([C@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@@H](C(=O)N([C@H](C(=O)N1)[C@@H]([C@H](C)C/C=C/C)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C
Peptide sequence
CYCLO[L-ALANYL-D-ALANYL-N-METHYL-L-LEUCYL-N-METHYL-L-LEUCYL-N-METHYL-D-VALYL-3-HYDROXY-N,4-DIMETHYL-L-2-AMINO-6-OCTENOYL-L-2-AMINOBUTANOYL-N-METHYLGLYCYL-N-METHYL-L-LEUCYL-L-VALYL-N-METHYL-L-LEUCYL]
RTECS
Not Applicable
UN #'S
Not Applicable
PACKING GROUP
Not Applicable
HAZARD CLASS
Not Applicable
Handling
TOXIC Use only in area provided with appropriate exhaust ventilation. Keep away from heat and source of ignition. Empty containers pose a fire risk, evaporate residue under fume hood. Ground all equipment containing material. Do not breathe dust.
GHS PICTOGRAMS
Handling TOXIC Use only in area provided with appropriate exhaust ventilation. Keep away from heat and source of ignition. Empty containers pose a fire risk, evaporate residue under fume hood. Ground all equipment containing material. Do not breathe dust.
UN #'S Not Applicable
Packing Group Not Applicable
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